| Gene Information | |
|---|---|
| Gene Name | WDR81 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1941 |
| Protein Names | WD repeat-containing protein 81 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000167716 ) 3 ( ENSG00000276021 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q562E7 |
| Gene Card | WDR81 |
| Uniprot ID | Q562E7 |
| Pfam | PF02138; PF00400 |
| In ASD | no |
| Allosteric Prediction | no (-0.999595154) |
| Ortholog in Animals | Alpaca_ WDR81 ( ortholog_one2one ) Dog_ WDR81 ( ortholog_one2one ) GuineaPig_ WDR81 ( ortholog_one2one ) Macaque_ WDR81 ( ortholog_one2one ) Mouse_ Wdr81 ( ortholog_one2one ) Pig_ WDR81 ( ortholog_one2one ) Rat_ Wdr81 ( ortholog_one2one ) Rabbit_ WDR81 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DAW1, WDR43, WDR7, COP1, TBL2, POC1B, WDR88, PAFAH1B1, WDR17, NWD1, WDR62, PAK1IP1, DCAF4L1, WDR27, WDR5B, WDR5, NEDD1, MAPKBP1, AHI1, TEP1, SNRNP40, WDR75, POC1A, DCAF4L2, DCAF4, WDR38 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. In the brain, highest levels in cerebellum and corpus callosum. {ECO:0000269|PubMed:21885617}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);0.1(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs730882206 rs587776906 rs3809870 |
| Subcellular location [CC] | Early endosome membrane {ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989}; Peripheral membrane protein {ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989}. Late endosome membrane {ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989, ECO:0000269|PubMed:28404643}. Lysosome membrane {ECO:0000269|PubMed:27126989}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:28404643}. Mitochondrion {ECO:0000269|PubMed:28404643}. Cytoplasm, cytosol {ECO:0000269|PubMed:27126989}. |
| Mouse PG classification | HPG |
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