| Gene Information | |
|---|---|
| Gene Name | WDR73 |
| Organism | Homo sapiens (Human) |
| Gene Length | 378 |
| Protein Names | WD repeat-containing protein 73 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000177082 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q6P4I2 |
| Gene Card | WDR73 |
| Uniprot ID | Q6P4I2 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.389184608) |
| Ortholog in Animals | Alpaca_ WDR73 ( ortholog_one2one ) Dog_ WDR73 ( ortholog_one2one ) GuineaPig_ WDR73 ( ortholog_one2one ) Macaque_ WDR73 ( ortholog_one2one ) Mouse_ Wdr73 ( ortholog_one2one ) Pig_ WDR73 ( ortholog_one2one ) Rat_ Wdr73 ( ortholog_one2one ) Rabbit_ WDR73 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GRWD1, RBBP4, GEMIN5, WDR59, ERCC8, WDR77, RBBP7, PEX7, WDR24 |
| Tissue | NA |
| Tissue Specificity | Expressed in kidney and brain. In the kidney, expressed in glomeruli, most probably in podocytes, and in tubules (at protein level). In the brain, expressed in the cerebellum, with high levels in Purkinje cells and their projecting axons, in the deep cerebellar nuclei and in pyramidal neurons of the cerebral cortex (at protein level). In the white matter, mainly present in astrocytes, but not in oligodendrocytes (at protein level). Also highly expressed in endothelial cells of cerebral capillaries (at protein level). {ECO:0000269|PubMed:25466283}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.085714(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11073619 |
| Subcellular location [CC] | Cytoplasm, cytosol. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:25466283}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:25466283}. Cleavage furrow {ECO:0000269|PubMed:25466283}. Note=During interphase, located in the cytosol. During mitosis, accumulates at the spindle poles and microtubule asters and later in the cleavage furrow. {ECO:0000269|PubMed:25466283}. |
| Mouse PG classification | NA |
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