| Gene Information | |
|---|---|
| Gene Name | IRE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 977 |
| Protein Names | Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O75460 |
| Gene Card | ERN1 |
| Uniprot ID | O75460 |
| Pfam | PF00069; PF06479 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. High levels observed in pancreatic tissue. {ECO:0000269|PubMed:9637683}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2HZ6 (X-ray 3.10A ) 3P23 (X-ray 2.70A ) 4U6R (X-ray 2.50A ) 4YZ9 (X-ray 2.46A ) 4YZC (X-ray 2.49A ) 4YZD (X-ray 3.10A ) 4Z7G (X-ray 2.60A ) 4Z7H (X-ray 2.90A ) 5HGI (X-ray 2.58A ) 6HV0 (X-ray 2.73A ) 6HX1 (X-ray 2.14A ) 6SHC (X-ray 3.55A ) 6URC (X-ray 2.20A ) 6W39 (X-ray 1.74A ) 6W3A (X-ray 2.61A ) 6W3B (X-ray 2.57A ) 6W3C (X-ray 2.30A ) 6W3E (X-ray 2.74A ) 6W3K (X-ray 2.08A ) 6XDB (X-ray 2.45A ) 6XDD (X-ray 2.40A ) 6XDF (X-ray 2.54A ) 7BMK (X-ray 1.85A ) |
| DBSNP | rs1397145500 rs55869215 rs186305118 rs146710304 rs918253870 rs1279653488 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:9637683}; Single-pass type I membrane protein {ECO:0000269|PubMed:9637683}. |
| Mouse PG classification | NA |
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