| Gene Information | |
|---|---|
| Gene Name | WDR62 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1518 |
| Protein Names | WD repeat-containing protein 62 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000075702 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O43379 |
| Gene Card | WDR62 |
| Uniprot ID | O43379 |
| Pfam | PF12894; PF00400 |
| In ASD | no |
| Allosteric Prediction | no (-0.779336626) |
| Ortholog in Animals | Alpaca_ WDR62 ( ortholog_one2one ) Dog_ WDR62 ( ortholog_one2one ) GuineaPig_ WDR62 ( ortholog_one2one ) Macaque_ WDR62 ( ortholog_one2one ) Mouse_ Wdr62 ( ortholog_one2one ) Pig_ WDR62 ( ortholog_one2one ) Rat_ NEWGENE_1306714 ( ortholog_one2one ) Rabbit_ WDR62 ( ortholog_one2one ) |
| Ohnologs | MAPKBP1 |
| Paralogs | DAW1, WDR43, WDR7, COP1, TBL2, POC1B, WDR88, PAFAH1B1, WDR17, NWD1, PAK1IP1, DCAF4L1, WDR27, WDR5B, WDR5, NEDD1, MAPKBP1, AHI1, TEP1, SNRNP40, WDR75, WDR81, POC1A, DCAF4L2, DCAF4, WDR38 |
| Tissue | testis |
| Tissue Specificity | Present in fetal brain, enriched within the ventricular and subventricular zone (at protein level). In the embryonic brain it is expressed in mitotic neural precursor cells. {ECO:0000269|PubMed:20890279}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs387907084 rs267607176 rs12327568 rs387907082 rs387907083 rs147875659 rs2285745 rs2074435 rs35811023 rs17851503 rs1008328 rs373781801 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:21496009}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:20890279, ECO:0000269|PubMed:28089251}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:21496009, ECO:0000269|PubMed:26297806}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:26297806}. Note=Shows cell cycle-dependent localization. Accumulates to the spindle pole during mitosis. Colocalizes with CDK5RAP2, CEP152 and WDR62 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles. {ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}. |
| Mouse PG classification | NA |
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