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Gene Information
Gene Name
WDR5
Organism
Homo sapiens (Human)
Gene Length
334
Protein Names
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Target Name
NA
Target Type
NA
Gene Age
1488 ( ENSG00000196363 )
Evolutionary Stage
Euk+Bac
AlphaFoldDB
P61964
Gene Card
WDR5
Uniprot ID
P61964
Pfam
PF00400
In ASD
no
Allosteric Prediction
yes (0.015328378)
Ortholog in Animals
Alpaca_ WDR5 ( ortholog_one2one )
Dog_ WDR5 ( ortholog_one2one )
GuineaPig_ WDR5 ( ortholog_one2one )
Macaque_ WDR5 ( ortholog_one2one )
Mouse_ Wdr5 ( ortholog_one2one )
Pig_ WDR5 ( ortholog_one2one )
Rat_ Wdr5 ( ortholog_one2one )
Ohnologs
NA
Paralogs
WDR5B, DAW1, WDR43, WDR7, COP1, TBL2, POC1B, WDR88, PAFAH1B1, WDR17, NWD1, WDR62, PAK1IP1, DCAF4L1, WDR27, NEDD1, MAPKBP1, AHI1, TEP1, SNRNP40, WDR75, WDR81, POC1A, DCAF4L2, DCAF4, WDR38
Tissue
NA
Tissue Specificity
NA
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);0.015276(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
2CNX
(X-ray
2.10A
)
2CO0
(X-ray
2.25A
)
2G99
(X-ray
1.90A
)
2G9A
(X-ray
2.70A
)
2GNQ
(X-ray
1.80A
)
2H13
(X-ray
1.58A
)
2H14
(X-ray
1.48A
)
2H68
(X-ray
1.79A
)
2H6K
(X-ray
1.89A
)
2H6N
(X-ray
1.50A
)
2H6Q
(X-ray
1.87A
)
2H9L
(X-ray
1.75A
)
2H9M
(X-ray
1.90A
)
2H9N
(X-ray
2.00A
)
2H9P
(X-ray
1.91A
)
2O9K
(X-ray
1.90A
)
3EG6
(X-ray
1.72A
)
3EMH
(X-ray
1.37A
)
3MXX
(X-ray
2.05A
)
3N0D
(X-ray
2.30A
)
3N0E
(X-ray
2.50A
)
3P4F
(X-ray
2.35A
)
3PSL
(X-ray
1.70A
)
3SMR
(X-ray
1.82A
)
3UR4
(X-ray
1.80A
)
3UVK
(X-ray
1.40A
)
3UVL
(X-ray
2.20A
)
3UVM
(X-ray
1.57A
)
3UVN
(X-ray
1.79A
)
3UVO
(X-ray
2.20A
)
4A7J
(X-ray
1.90A
)
4CY1
(X-ray
1.50A
)
4CY2
(X-ray
2.00A
)
4ERQ
(X-ray
1.91A
)
4ERY
(X-ray
1.30A
)
4ERZ
(X-ray
1.75A
)
4ES0
(X-ray
1.82A
)
4ESG
(X-ray
1.70A
)
4EWR
(X-ray
1.50A
)
4GM3
(X-ray
3.39A
)
4GM8
(X-ray
2.60A
)
4GM9
(X-ray
2.10A
)
4GMB
(X-ray
2.78A
)
4IA9
(X-ray
1.66A
)
4O45
(X-ray
1.87A
)
4QL1
(X-ray
1.50A
)
4Y7R
(X-ray
1.90A
)
5EAL
(X-ray
1.80A
)
5EAM
(X-ray
1.80A
)
5EAP
(X-ray
1.73A
)
5EAR
(X-ray
1.80A
)
5M23
(X-ray
1.97A
)
5M25
(X-ray
2.43A
)
5SXM
(X-ray
2.00A
)
5VFC
(X-ray
1.64A
)
6BYN
(X-ray
2.69A
)
6D9X
(X-ray
1.83A
)
6DAI
(X-ray
1.63A
)
6DAK
(X-ray
1.60A
)
6DAR
(X-ray
1.88A
)
6DAS
(X-ray
1.80A
)
6DY7
(X-ray
1.90A
)
6DYA
(X-ray
2.56A
)
6E1Y
(X-ray
1.22A
)
6E1Z
(X-ray
1.10A
)
6E22
(X-ray
1.60A
)
6E23
(X-ray
1.66A
)
6IAM
(X-ray
1.51A
)
6KIU
(EM
3.20A
)
6KIV
(EM
4.00A
)
6KIW
(EM
4.00A
)
6KIX
(EM
4.10A
)
6KIZ
(EM
4.50A
)
6OFZ
(X-ray
1.85A
)
6OI0
(X-ray
1.92A
)
6OI1
(X-ray
1.68A
)
6OI2
(X-ray
1.68A
)
6OI3
(X-ray
1.66A
)
6PG3
(X-ray
2.04A
)
6PG4
(X-ray
1.60A
)
6PG5
(X-ray
1.99A
)
6PG6
(X-ray
1.68A
)
6PG7
(X-ray
2.45A
)
6PG8
(X-ray
1.67A
)
6PG9
(X-ray
1.75A
)
6PGA
(X-ray
2.45A
)
6PGB
(X-ray
1.73A
)
6PGC
(X-ray
1.81A
)
6PGD
(X-ray
1.50A
)
6PGE
(X-ray
1.76A
)
6PGF
(X-ray
1.54A
)
6PWV
(EM
6.20A
)
6PWW
(EM
4.40A
)
6U5M
(X-ray
1.80A
)
6U5Y
(X-ray
1.53A
)
6U6W
(X-ray
1.20A
)
6U80
(X-ray
1.55A
)
6U8B
(X-ray
1.26A
)
6U8L
(X-ray
1.57A
)
6U8O
(X-ray
1.60A
)
6UCS
(X-ray
1.85A
)
6UFX
(X-ray
2.02A
)
6UHY
(X-ray
1.26A
)
6UHZ
(X-ray
1.26A
)
6UIF
(X-ray
1.60A
)
6UIK
(X-ray
1.60A
)
6UJ4
(X-ray
1.53A
)
6UJH
(X-ray
1.49A
)
6UJJ
(X-ray
1.73A
)
6UJL
(X-ray
1.60A
)
6UOZ
(X-ray
1.53A
)
6W5I
(EM
6.90A
)
6W5M
(EM
4.60A
)
6W5N
(EM
6.00A
)
6WJQ
(X-ray
2.71A
)
7AXP
(X-ray
2.43A
)
7AXQ
(X-ray
1.56A
)
7AXS
(X-ray
1.88A
)
7AXU
(X-ray
1.68A
)
7AXX
(X-ray
1.79A
)
7BCY
(X-ray
1.50A
)
7BED
(X-ray
1.26A
)
7CFP
(X-ray
1.60A
)
7CFQ
(X-ray
1.60A
)
7DNO
(X-ray
2.03A
)
7JTO
(X-ray
1.70A
)
7JTP
(X-ray
2.12A
)
7MBM
(EM
-
)
7MBN
(EM
-
)
7Q2J
(X-ray
2.50A
)
7U9Y
(X-ray
1.90A
)
7UAS
(X-ray
1.81A
)
DBSNP
NA
Subcellular location [CC]
Nucleus {ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:34850113}.
Mouse PG classification
NA
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