| Gene Information | |
|---|---|
| Gene Name | WDR45B |
| Organism | Homo sapiens (Human) |
| Gene Length | 344 |
| Protein Names | WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat-containing protein 45-like) (WDR45-like protein) (WD repeat-containing protein 45B) (WIPI49-like protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000141580 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q5MNZ6 |
| Gene Card | WDR45B |
| Uniprot ID | Q5MNZ6 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.368226166) |
| Ortholog in Animals | Alpaca_ WDR45B ( ortholog_one2one ) Dog_ WDR45B ( ortholog_one2one ) GuineaPig_ WDR45B ( ortholog_one2one ) Macaque_ WDR45B ( ortholog_one2many ) Mouse_ Wdr45b ( ortholog_one2one ) Pig_ WDR45B ( ortholog_one2one ) Rat_ Wdr45b ( ortholog_one2one ) Rabbit_ WDR45B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | WIPI1, WDR45, WIPI2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Up-regulated in a variety of tumor tissues including ovarian and uterine cancers. {ECO:0000269|PubMed:15602573}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6IYY (X-ray 1.80A ) 6KLR (X-ray 2.21A ) |
| DBSNP | NA |
| Subcellular location [CC] | Preautophagosomal structure {ECO:0000269|PubMed:28561066}. Lysosome {ECO:0000269|PubMed:28561066}. |
| Mouse PG classification | NA |
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