| Gene Information | |
|---|---|
| Gene Name | WDR45 |
| Organism | Homo sapiens (Human) |
| Gene Length | 360 |
| Protein Names | WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000196998 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y484 |
| Gene Card | WDR45 |
| Uniprot ID | Q9Y484 |
| Pfam | PF00400 |
| In ASD | no |
| Allosteric Prediction | no (-0.929237803) |
| Ortholog in Animals | Alpaca_ WDR45 ( ortholog_one2one ) Dog_ PRAF2 ( ortholog_one2one ) GuineaPig_ WDR45 ( ortholog_one2one ) Macaque_ WDR45 ( ortholog_one2one ) Mouse_ Wdr45 ( ortholog_one2one ) Pig_ WDR45 ( ortholog_one2one ) Rat_ Wdr45 ( ortholog_one2one ) Rabbit_ WDR45 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | WDR45B, WIPI1, WIPI2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, with high expression in skeletal muscle and heart. Weakly expressed in liver and placenta. Expression is down-regulated in pancreatic and in kidney tumors. {ECO:0000269|PubMed:15602573}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Preautophagosomal structure {ECO:0000269|PubMed:21802374, ECO:0000269|PubMed:28561066}. Cytoplasm {ECO:0000269|PubMed:21802374}. Note=Diffusely localized in the cytoplasm under nutrient-rich conditions. Localizes to autophagic structures during starvation-induced autophagy. {ECO:0000269|PubMed:21802374}. |
| Mouse PG classification | NA |
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