| Gene Information | |
|---|---|
| Gene Name | EIF2AK3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1116 |
| Protein Names | Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) |
| Target Name | prkr-like endoplasmic reticulum kinase |
| Target Type | Patented-recorded target |
| Gene Age | 1488 ( ENSG00000172071 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NZJ5 |
| Gene Card | EIF2AK3 |
| Uniprot ID | Q9NZJ5 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.611754077) |
| Ortholog in Animals | Alpaca_ EIF2AK3 ( ortholog_one2one ) Dog_ EIF2AK3 ( ortholog_one2one ) GuineaPig_ EIF2AK3 ( ortholog_one2one ) Macaque_ EIF2AK3 ( ortholog_one2one ) Mouse_ Eif2ak3 ( ortholog_one2one ) Pig_ EIF2AK3 ( ortholog_one2one ) Rat_ Eif2ak3 ( ortholog_one2one ) Rabbit_ EIF2AK3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | STK35, PKMYT1, EIF2AK4, WEE2, EIF2AK2, WEE1, PDIK1L, EIF2AK1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. A high level expression is seen in secretory tissues. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.007657(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 4G31 (X-ray 2.28A ) 4G34 (X-ray 2.70A ) 4M7I (X-ray 2.34A ) 4X7H (X-ray 2.00A ) 4X7J (X-ray 2.30A ) 4X7K (X-ray 1.80A ) 4X7L (X-ray 1.90A ) 4X7N (X-ray 2.35A ) 4X7O (X-ray 2.65A ) 4YZS (X-ray 3.14A ) 5SV7 (X-ray 3.21A ) 7MF0 (X-ray 2.81A ) |
| DBSNP | rs867529 rs13045 rs55791823 rs121908569 rs1805165 rs55861585 |
| Subcellular location [CC] | Endoplasmic reticulum membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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