| Gene Information | |
|---|---|
| Gene Name | DAPK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 370 |
| Protein Names | Death-associated protein kinase 2 (DAP kinase 2) (EC 2.7.11.1) (DAP-kinase-related protein 1) (DRP-1) |
| Target Name | death-associated protein kinase 2 |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000035664 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UIK4 |
| Gene Card | DAPK2 |
| Uniprot ID | Q9UIK4 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | no (-0.431542986) |
| Ortholog in Animals | Alpaca_ DAPK2 ( ortholog_one2one ) Dog_ DAPK2 ( ortholog_one2one ) GuineaPig_ DAPK2 ( ortholog_one2one ) Macaque_ DAPK2 ( ortholog_one2one ) Mouse_ Dapk2 ( ortholog_one2one ) Pig_ DAPK2 ( ortholog_one2one ) Rat_ Dapk2 ( ortholog_one2one ) Rabbit_ DAPK2 ( ortholog_one2one ) |
| Ohnologs | DAPK3 |
| Paralogs | DAPK1, DAPK3, MYLK, NEXN |
| Tissue | skeletal.muscle, thyroid |
| Tissue Specificity | Expressed in neutrophils and eosinophils (PubMed:24163421). Isoform 2 is expressed in embryonic stem cells (at protein level). Isoform 1 is ubiquitously expressed in all tissue types examined with high levels in heart, lung and skeletal muscle. {ECO:0000269|PubMed:10376525, ECO:0000269|PubMed:17347302, ECO:0000269|PubMed:21408167, ECO:0000269|PubMed:24163421}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1WMK (X-ray 3.60A ) 1WRZ (X-ray 2.00A ) 1Z9X (X-ray 3.93A ) 1ZUZ (X-ray 1.91A ) 1ZWS (X-ray 2.90A ) 2A27 (X-ray 3.00A ) 2A2A (X-ray 1.47A ) 2CKE (X-ray 2.80A ) 6PAW (X-ray 2.95A ) 7A6R (X-ray 2.70A ) 7A6Y (X-ray 2.50A ) |
| DBSNP | rs56047843 rs34270163 |
| Subcellular location [CC] | Cytoplasm. Cytoplasmic vesicle, autophagosome lumen. |
| Mouse PG classification | NA |
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