| Gene Information | |
|---|---|
| Gene Name | GDF5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 501 |
| Protein Names | Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin) |
| Target Name | growth/differentiation factor 5 |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000125965 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P43026 |
| Gene Card | GDF5 |
| Uniprot ID | P43026 |
| Pfam | PF00019; PF00688 |
| In ASD | no |
| Allosteric Prediction | no (-0.78729576) |
| Ortholog in Animals | Alpaca_ GDF5 ( ortholog_one2one ) Dog_ GDF5 ( ortholog_one2one ) GuineaPig_ GDF5 ( ortholog_one2one ) Macaque_ GDF5 ( ortholog_one2one ) Mouse_ Gdf5 ( ortholog_one2one ) Pig_ GDF5 ( ortholog_one2one ) Rat_ Gdf5 ( ortholog_one2one ) Rabbit_ GDF5 ( ortholog_one2one ) |
| Ohnologs | BMP5, BMP4, GDF7, GDF6, BMP10, BMP8A |
| Paralogs | BMP3, MSTN, INHBC, GDF15, BMP6, INHBA, GDF6, TGFB3, BMP2, BMP10, TGFB1, INHA, GDF9, GDF11, BMP5, BMP7, INHBB, GDF1, GDF2, BMP4, LEFTY1, LEFTY2, GDF3, INHBE, GDF7, GDF10, BMP15, TGFB2, BMP8A, BMP8B, NODAL |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in long bones during embryonic development. Expressed in monocytes (at protein level). {ECO:0000269|PubMed:11276205}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.001000(Rat);0.071429(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1WAQ (X-ray 2.28A ) 2BHK (X-ray 2.40A ) 3EVS (X-ray 2.10A ) 3QB4 (X-ray 2.28A ) 5HK5 (X-ray 2.90A ) 6Z3G (X-ray 2.78A ) 6Z3H (X-ray 3.16A ) 6Z3J (X-ray 1.65A ) 6Z3L (X-ray 2.51A ) 6Z3M (X-ray 5.50A ) |
| DBSNP | rs34534075 rs28936397 rs224331 rs121909349 rs121909350 rs397514668 rs397514519 rs74315387 rs121909351 rs74315388 rs28936683 rs121909347 rs74315389 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:11276205}. Cell membrane {ECO:0000269|PubMed:11276205}. |
| Mouse PG classification | HPG |
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