| Gene Information | |
|---|---|
| Gene Name | WAS |
| Organism | Homo sapiens (Human) |
| Gene Length | 502 |
| Protein Names | Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp) |
| Target Name | wiskott-aldrich syndrome protein |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000015285 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P42768 |
| Gene Card | WAS |
| Uniprot ID | P42768 |
| Pfam | PF00786; PF00568; PF02205 |
| In ASD | yes |
| Allosteric Prediction | yes (0.714667808) |
| Ortholog in Animals | Dog_ WAS ( ortholog_one2one ) GuineaPig_ WAS ( ortholog_one2one ) Macaque_ WAS ( ortholog_one2one ) Mouse_ Was ( ortholog_one2one ) Pig_ WAS ( ortholog_one2one ) Rat_ Was ( ortholog_one2one ) Rabbit_ WAS ( ortholog_one2one ) |
| Ohnologs | WASL |
| Paralogs | WASL |
| Tissue | adipose.tissue, lung, spleen |
| Tissue Specificity | Expressed predominantly in the thymus. Also found, to a much lesser extent, in the spleen. {ECO:0000269|PubMed:8069912}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001748(Rat);0.037143(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1CEE (NMR - ) 1EJ5 (NMR - ) 1T84 (NMR - ) 2A3Z (X-ray 2.08A ) 2K42 (NMR - ) 2OT0 (X-ray 2.05A ) |
| DBSNP | rs1557006239 rs132630273 rs132630269 rs132630275 rs782290433 rs132630272 rs132630268 rs132630268 rs139857045 rs146220228 rs132630274 rs132630276 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:8625410}. Nucleus {ECO:0000269|PubMed:20574068, ECO:0000269|PubMed:29925947}. |
| Mouse PG classification | NA |
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