| Gene Information | |
|---|---|
| Gene Name | WAPL |
| Organism | Homo sapiens (Human) |
| Gene Length | 1190 |
| Protein Names | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000062650 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q7Z5K2 |
| Gene Card | WAPL |
| Uniprot ID | Q7Z5K2 |
| Pfam | PF07814 |
| In ASD | no |
| Allosteric Prediction | no (-0.280148669) |
| Ortholog in Animals | Alpaca_ WAPL ( ortholog_one2one ) Dog_ WAPL ( ortholog_one2one ) GuineaPig_ WAPL ( ortholog_one2one ) Macaque_ WAPL ( ortholog_one2one ) Mouse_ Wapl ( ortholog_one2one ) Pig_ WAPL ( ortholog_one2one ) Rat_ Wapl ( ortholog_one2one ) Rabbit_ WAPL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart. {ECO:0000269|PubMed:15150110, ECO:0000269|PubMed:15383329}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.149869(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4K6J (X-ray 2.62A ) 5HDT (X-ray 2.71A ) |
| DBSNP | rs10887621 rs1564570621 |
| Subcellular location [CC] | [Isoform 2]: Nucleus.; Nucleus. Chromosome. Cytoplasm. Note=Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase. |
| Mouse PG classification | NA |
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