| Gene Information | |
|---|---|
| Gene Name | WWP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 870 |
| Protein Names | NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2) |
| Target Name | wwp2 messenger rna |
| Target Type | Literature-reported target |
| Gene Age | 424 ( ENSG00000198373 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O00308 |
| Gene Card | WWP2 |
| Uniprot ID | O00308 |
| Pfam | PF00632; PF00397 |
| In ASD | no |
| Allosteric Prediction | no (-0.485295811) |
| Ortholog in Animals | Alpaca_ WWP2 ( ortholog_one2one ) Dog_ WWP2 ( ortholog_one2one ) GuineaPig_ WWP2 ( ortholog_one2one ) Macaque_ WWP2 ( ortholog_one2one ) Mouse_ Wwp2 ( ortholog_one2one ) Pig_ WWP2 ( ortholog_one2one ) Rat_ Wwp2 ( ortholog_one2one ) Rabbit_ WWP2 ( ortholog_one2one ) |
| Ohnologs | ITCH, WWP1 |
| Paralogs | HERC4, NEDD4, HECTD1, NEDD4L, UBE3B, HUWE1, SMURF1, AREL1, UBR5, HERC2, HECW2, HERC3, WWP1, UBE3A, UBE3C, SMURF2, HACE1, HECTD2, HECTD4, ITCH, HECW1, TRIP12, HERC5, HERC6 |
| Tissue | NA |
| Tissue Specificity | Detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. Also detected in spleen and peripheral blood leukocytes. {ECO:0000269|PubMed:19274063, ECO:0000269|PubMed:9647693}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001364(Rat);0.009259(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4Y07 (X-ray 2.51A ) 5TJ7 (X-ray 2.60A ) 5TJ8 (X-ray 2.30A ) 5TJQ (X-ray 2.75A ) 6J1Z (X-ray 2.70A ) 6RSS (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:19274063, ECO:0000269|PubMed:20858735}. |
| Mouse PG classification | NA |
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