| Gene Information | |
|---|---|
| Gene Name | ENG |
| Organism | Homo sapiens (Human) |
| Gene Length | 658 |
| Protein Names | Endoglin (CD antigen CD105) |
| Target Name | endoglin cd105 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000106991 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P17813 |
| Gene Card | ENG |
| Uniprot ID | P17813 |
| Pfam | PF00100 |
| In ASD | no |
| Allosteric Prediction | yes (0.618210015) |
| Ortholog in Animals | Alpaca_ ENG ( ortholog_one2one ) Dog_ ENG ( ortholog_one2one ) GuineaPig_ ENG ( ortholog_one2one ) Macaque_ ENG ( ortholog_one2one ) Mouse_ Eng ( ortholog_one2one ) Pig_ ENG ( ortholog_one2one ) Rat_ Eng ( ortholog_one2one ) Rabbit_ ENG ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TGFBR3, TGFBR3L |
| Tissue | NA |
| Tissue Specificity | Detected on umbilical veil endothelial cells (PubMed:10625079). Detected in placenta (at protein level) (PubMed:1692830). Detected on endothelial cells (PubMed:1692830). {ECO:0000269|PubMed:10625079, ECO:0000269|PubMed:1692830}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001990(Rat);0.018182(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5HZV (X-ray 2.70A ) 5HZW (X-ray 4.45A ) 5I04 (X-ray 2.42A ) |
| DBSNP | rs35400405 rs1564466414 rs1252348200 rs1588585880 rs878853657 rs1588582695 rs1554810378 rs754136153 rs1060501415 rs763508329 rs1588580782 rs1800956 rs1830434129 rs121918401 rs1434169817 rs763475207 rs116330805 rs863223538 rs142896669 rs1060501421 rs375965489 rs1830302008 rs148002300 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10545596, ECO:0000269|PubMed:1326540, ECO:0000269|PubMed:1692830, ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:8370410}; Single-pass type I membrane protein {ECO:0000305|PubMed:1692830, ECO:0000305|PubMed:8370410}. |
| Mouse PG classification | HPG |
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