Gene Information
Gene NameVWF
OrganismHomo sapiens (Human)
Gene Length2813
Protein Namesvon Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)]
Target Namevon willebrand factor
Target TypeNA
Gene Age950 ( ENSG00000110799 )
Evolutionary StageEumetazoa
AlphaFoldDBNA
Gene CardVWF
Uniprot IDP04275
PfamPF08742; PF01826; PF00092; PF16164; PF00093; PF00094
In ASDyes
Allosteric Predictionyes (1.065494734)
Ortholog in AnimalsAlpaca_ VWF ( ortholog_one2one )
Dog_ VWF ( ortholog_one2one )
GuineaPig_ VWF ( ortholog_one2one )
Macaque_ VWF ( ortholog_one2one )
Mouse_ Vwf ( ortholog_one2one )
Pig_ VWF ( ortholog_one2one )
Rat_ Vwf ( ortholog_one2one )
Rabbit_ VWF ( ortholog_one2one )
OhnologsMUC6, OTOG, MUC2
ParalogsCHRDL1, MUC5B, KCP, CHRDL2, CHRD, VWCE, OTOGL, MUC6, MUC5AC, OTOG, ZAN, BMPER, TECTA, FCGBP, CRIM1, MUC2, MUC19, VWC2L, VWC2
TissueNA
Tissue SpecificityPlasma.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1AO3  (X-ray  2.20A  1ATZ  (X-ray  1.80A  1AUQ  (X-ray  2.30A  1FE8  (X-ray  2.03A  1FNS  (X-ray  2.00A  1IJB  (X-ray  1.80A  1IJK  (X-ray  2.60A  1M10  (X-ray  3.10A  1OAK  (X-ray  2.20A  1SQ0  (X-ray  2.60A  1U0N  (X-ray  2.95A  1UEX  (X-ray  2.85A  2ADF  (X-ray  1.90A  2MHP  (NMR  2MHQ  (NMR  3GXB  (X-ray  1.90A  3HXO  (X-ray  2.40A  3HXQ  (X-ray  2.69A  3PPV  (X-ray  1.90A  3PPW  (X-ray  1.90A  3PPX  (X-ray  1.91A  3PPY  (X-ray  2.00A  3ZQK  (X-ray  1.70A  4C29  (X-ray  2.20A  4C2A  (X-ray  2.08A  4C2B  (X-ray  2.80A  4DMU  (X-ray  2.80A  4NT5  (X-ray  3.28A  5BV8  (X-ray  1.59A  6FWN  (NMR  6N29  (X-ray  2.50A  7EOW  (X-ray  1.60A  7F49  (X-ray  2.09A  7KWO  (EM  2.90A  7P4N  (NMR  7PMV  (EM  3.70A  7PNF  (EM  4.35A  7ZWH  (EM  3.20A  8D3C  (EM  3.10A  8D3D  (EM  3.20A 
DBSNP rs61753997  rs1800387  rs62643626  rs1800377  rs1800378  rs61754010  rs61754011  rs2228317  rs61748476  rs1063856  rs61748477  rs121964894  rs216321  rs41276738  rs11064002  rs61748497  rs61748511  rs61749370  rs61749371  rs63524161  rs61749372  rs61749384  rs61749387  rs61749392  rs61749393  rs61749397  rs372028373  rs61749398  rs61749403  rs61750071  rs61750072  rs216311  rs1800382  rs61750088  rs61750089  rs1800383  rs61750101  rs267607342  rs1800385  rs1800386  rs61750117  rs61750577  rs61750117  rs61750579  rs61750580  rs61750581  rs61750584  rs61750588  rs61750590  rs61750596  rs61750615  rs34230288  rs2229446  rs61750630  rs61751298  rs7962217  rs61751305  rs61751310 
Subcellular location [CC]Secreted {ECO:0000269|PubMed:10961880}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:10961880}. Note=Localized to storage granules.
Mouse PG classificationHPG
click here to return to the previous page