| Gene Information | |
|---|---|
| Gene Name | VWF |
| Organism | Homo sapiens (Human) |
| Gene Length | 2813 |
| Protein Names | von Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)] |
| Target Name | von willebrand factor |
| Target Type | Successful target |
| Gene Age | 950 ( ENSG00000110799 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | NA |
| Gene Card | VWF |
| Uniprot ID | P04275 |
| Pfam | PF08742; PF01826; PF00092; PF16164; PF00093; PF00094 |
| In ASD | yes |
| Allosteric Prediction | yes (1.065494734) |
| Ortholog in Animals | Alpaca_ VWF ( ortholog_one2one ) Dog_ VWF ( ortholog_one2one ) GuineaPig_ VWF ( ortholog_one2one ) Macaque_ VWF ( ortholog_one2one ) Mouse_ Vwf ( ortholog_one2one ) Pig_ VWF ( ortholog_one2one ) Rat_ Vwf ( ortholog_one2one ) Rabbit_ VWF ( ortholog_one2one ) |
| Ohnologs | MUC6, OTOG, MUC2 |
| Paralogs | CHRDL1, MUC5B, KCP, CHRDL2, CHRD, VWCE, OTOGL, MUC6, MUC5AC, OTOG, ZAN, BMPER, TECTA, FCGBP, CRIM1, MUC2, MUC19, VWC2L, VWC2 |
| Tissue | NA |
| Tissue Specificity | Plasma. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1AO3 (X-ray 2.20A ) 1ATZ (X-ray 1.80A ) 1AUQ (X-ray 2.30A ) 1FE8 (X-ray 2.03A ) 1FNS (X-ray 2.00A ) 1IJB (X-ray 1.80A ) 1IJK (X-ray 2.60A ) 1M10 (X-ray 3.10A ) 1OAK (X-ray 2.20A ) 1SQ0 (X-ray 2.60A ) 1U0N (X-ray 2.95A ) 1UEX (X-ray 2.85A ) 2ADF (X-ray 1.90A ) 2MHP (NMR - ) 2MHQ (NMR - ) 3GXB (X-ray 1.90A ) 3HXO (X-ray 2.40A ) 3HXQ (X-ray 2.69A ) 3PPV (X-ray 1.90A ) 3PPW (X-ray 1.90A ) 3PPX (X-ray 1.91A ) 3PPY (X-ray 2.00A ) 3ZQK (X-ray 1.70A ) 4C29 (X-ray 2.20A ) 4C2A (X-ray 2.08A ) 4C2B (X-ray 2.80A ) 4DMU (X-ray 2.80A ) 4NT5 (X-ray 3.28A ) 5BV8 (X-ray 1.59A ) 6FWN (NMR - ) 6N29 (X-ray 2.50A ) 7EOW (X-ray 1.60A ) 7F49 (X-ray 2.09A ) 7KWO (EM 2.90A ) 7P4N (NMR - ) 7PMV (EM 3.70A ) 7PNF (EM 4.35A ) 7ZWH (EM 3.20A ) 8D3C (EM 3.10A ) 8D3D (EM 3.20A ) |
| DBSNP | rs61753997 rs1800387 rs62643626 rs1800377 rs1800378 rs61754010 rs61754011 rs2228317 rs61748476 rs1063856 rs61748477 rs121964894 rs216321 rs41276738 rs11064002 rs61748497 rs61748511 rs61749370 rs61749371 rs63524161 rs61749372 rs61749384 rs61749387 rs61749392 rs61749393 rs61749397 rs372028373 rs61749398 rs61749403 rs61750071 rs61750072 rs216311 rs1800382 rs61750088 rs61750089 rs1800383 rs61750101 rs267607342 rs1800385 rs1800386 rs61750117 rs61750577 rs61750117 rs61750579 rs61750580 rs61750581 rs61750584 rs61750588 rs61750590 rs61750596 rs61750615 rs34230288 rs2229446 rs61750630 rs61751298 rs7962217 rs61751305 rs61751310 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:10961880}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:10961880}. Note=Localized to storage granules. |
| Mouse PG classification | HPG |
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