| Gene Information | |
|---|---|
| Gene Name | NOX5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 765 |
| Protein Names | NADPH oxidase 5 (EC 1.6.3.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000255346 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96PH1 |
| Gene Card | NOX5 |
| Uniprot ID | Q96PH1 |
| Pfam | PF13202; PF13405; PF08022; PF01794; PF08030 |
| In ASD | no |
| Allosteric Prediction | yes (0.071271509) |
| Ortholog in Animals | Alpaca_ NOX5 ( ortholog_one2one ) Dog_ NOX5 ( ortholog_one2one ) Macaque_ NOX5 ( ortholog_one2one ) Pig_ NOX5 ( ortholog_one2one ) Rabbit_ NOX5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NOX3, NOX1, DUOX1, NOX4, DUOX2, CYBB |
| Tissue | spleen |
| Tissue Specificity | Mainly expressed in pachytene spermatocytes of testis and in lymphocyte-rich areas of spleen and lymph nodes. Isoform v1 is expressed in spleen. Isoform v2 is expressed in testis. Also detected in ovary, placenta, pancreas, cardiac fibroblasts. Expressed in B-cells and prostate malignant cells. Isoform v1 and isoform v3 are expressed in epithelial colorectal adenocarcinoma cells. Isoform v2 and isoform v4 are expressed in endothelial cells. Isoform v1, isoform v2, isoform v3 and isoform v4 are expressed in pulmonary artery smooth muscle cells. Isoform v2 and isoform v5 are expressed in microvascular endothelial cells (at protein level). {ECO:0000269|PubMed:11376945, ECO:0000269|PubMed:11483596, ECO:0000269|PubMed:12686516, ECO:0000269|PubMed:16179589, ECO:0000269|PubMed:16339585, ECO:0000269|PubMed:17275676}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6SZ5 (X-ray 2.23A ) |
| DBSNP | rs2277552 rs7168025 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.; [Isoform v2]: Endoplasmic reticulum.; [Isoform v5]: Endoplasmic reticulum. |
| Mouse PG classification | NA |
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