| Gene Information | |
|---|---|
| Gene Name | VWA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 755 |
| Protein Names | von Willebrand factor A domain-containing protein 2 (A domain-containing protein similar to matrilin and collagen) (AMACO) (Colon cancer secreted protein 2) (CCSP-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000165816 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q5GFL6 |
| Gene Card | VWA2 |
| Uniprot ID | Q5GFL6 |
| Pfam | PF00008; PF00092 |
| In ASD | no |
| Allosteric Prediction | no (-1.339004865) |
| Ortholog in Animals | Alpaca_ VWA2 ( ortholog_one2one ) Dog_ VWA2 ( ortholog_one2one ) GuineaPig_ VWA2 ( ortholog_one2one ) Macaque_ VWA2 ( ortholog_one2one ) Mouse_ Vwa2 ( ortholog_one2one ) Pig_ VWA2 ( ortholog_one2one ) Rat_ Vwa2 ( ortholog_one2one ) Rabbit_ VWA2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | COL12A1, COL6A6, MATN2, MATN3, MATN4, VIT, VWA1, COL6A3, MATN1, COL14A1, COL6A5, COCH |
| Tissue | NA |
| Tissue Specificity | Expression is generally absent in normal colon and other normal body tissues, but it is induced an average of 78-fold in Stage II, III, and IV colon cancers, as well as in colon adenomas and colon cancer cell lines. {ECO:0000269|PubMed:15580307}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs9664945 rs597371 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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