| Gene Information | |
|---|---|
| Gene Name | THSD7A |
| Organism | Homo sapiens (Human) |
| Gene Length | 1657 |
| Protein Names | Thrombospondin type-1 domain-containing protein 7A [Cleaved into: Thrombospondin type-1 domain-containing protein 7A, soluble form] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000005108 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UPZ6 |
| Gene Card | THSD7A |
| Uniprot ID | Q9UPZ6 |
| Pfam | PF19028; PF00090 |
| In ASD | no |
| Allosteric Prediction | no (-0.921670385) |
| Ortholog in Animals | Alpaca_ THSD7A ( ortholog_one2one ) Dog_ THSD7A ( ortholog_one2one ) GuineaPig_ THSD7A ( ortholog_one2one ) Macaque_ THSD7A ( ortholog_one2one ) Mouse_ Thsd7a ( ortholog_one2one ) Pig_ THSD7A ( ortholog_one2one ) Rat_ Thsd7a ( ortholog_one2one ) Rabbit_ THSD7A ( ortholog_one2one ) |
| Ohnologs | THSD7B |
| Paralogs | SPON2, THSD7B, SPON1 |
| Tissue | NA |
| Tissue Specificity | Detected on kidney podocytes along the glomerular capillary wall (at protein level). {ECO:0000269|PubMed:25394321}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2074599 rs47 rs2285744 rs1432 rs56264449 |
| Subcellular location [CC] | [Thrombospondin type-1 domain-containing protein 7A]: Cell membrane {ECO:0000269|PubMed:22194972, ECO:0000269|PubMed:25394321, ECO:0000269|PubMed:27214550}; Single-pass type I membrane protein {ECO:0000269|PubMed:22194972}. Cell projection {ECO:0000250|UniProtKB:Q69ZU6}. Note=Detected on podocyte foot processes. {ECO:0000250|UniProtKB:Q69ZU6}.; [Thrombospondin type-1 domain-containing protein 7A, soluble form]: Secreted {ECO:0000269|PubMed:22194972}. Note=Proteolytic cleavage in the extracellular region generates a 210 kDa soluble form. {ECO:0000269|PubMed:22194972}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |