| Gene Information | |
|---|---|
| Gene Name | VTN |
| Organism | Homo sapiens (Human) |
| Gene Length | 478 |
| Protein Names | Vitronectin (VN) (S-protein) (Serum-spreading factor) (V75) [Cleaved into: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B] |
| Target Name | vitronectin |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000109072 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P04004 |
| Gene Card | VTN |
| Uniprot ID | P04004 |
| Pfam | PF00045; PF01033 |
| In ASD | no |
| Allosteric Prediction | yes (0.781301874) |
| Ortholog in Animals | Alpaca_ VTN ( ortholog_one2one ) Dog_ VTN ( ortholog_one2one ) GuineaPig_ VTN ( ortholog_one2one ) Macaque_ VTN ( ortholog_one2one ) Mouse_ Vtn ( ortholog_one2one ) Pig_ VTN ( ortholog_one2one ) Rat_ Vtn ( ortholog_one2one ) Rabbit_ VTN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PRG4 |
| Tissue | liver |
| Tissue Specificity | Expressed in the retina pigment epithelium (at protein level) (PubMed:25136834). Expressed in plasma (at protein level) (PubMed:2448300). Expressed in serum (at protein level) (PubMed:29567995). {ECO:0000269|PubMed:2448300, ECO:0000269|PubMed:25136834, ECO:0000269|PubMed:29567995}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001704(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1OC0 (X-ray 2.28A ) 1S4G (NMR - ) 1SSU (NMR - ) 2JQ8 (NMR - ) 3BT1 (X-ray 2.80A ) 3BT2 (X-ray 2.50A ) 4K24 (X-ray 4.50A ) 6O5E (X-ray 1.90A ) 7RJ9 (X-ray 1.70A ) |
| DBSNP | rs2227741 rs2227723 rs704 |
| Subcellular location [CC] | Secreted, extracellular space {ECO:0000269|PubMed:2448300, ECO:0000269|PubMed:29567995}.; Parasitophorous vacuole {ECO:0000269|PubMed:29567995}. Note=(Microbial infection) In P.falciparum-infected red blood cells, VTN internalization is detected at the early trophozoite stage (PubMed:29567995). Colocalizes with SERA5 at the schizont stage and with SERA5 P47 at the merozoite surface (PubMed:29567995). {ECO:0000269|PubMed:29567995}. |
| Mouse PG classification | NA |
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