| Gene Information | |
|---|---|
| Gene Name | PRKD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 878 |
| Protein Names | Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000105287 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BZL6 |
| Gene Card | PRKD2 |
| Uniprot ID | Q9BZL6 |
| Pfam | PF00130; PF00069 |
| In ASD | no |
| Allosteric Prediction | no (-0.152805087) |
| Ortholog in Animals | Alpaca_ PRKD2 ( ortholog_one2one ) Dog_ PRKD2 ( ortholog_one2one ) GuineaPig_ PRKD2 ( ortholog_one2one ) Macaque_ PRKD2 ( ortholog_one2one ) Mouse_ Prkd2 ( ortholog_one2one ) Pig_ PRKD2 ( ortholog_one2one ) Rat_ Prkd2 ( ortholog_one2one ) Rabbit_ PRKD2 ( ortholog_one2one ) |
| Ohnologs | PRKD3, PRKD1 |
| Paralogs | PRKD1, PRKD3 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:11062248}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2COA (NMR - ) 3BGM (X-ray 1.60A ) 4NNX (X-ray 2.10A ) 4NNY (X-ray 1.90A ) |
| DBSNP | rs45455991 rs55716765 rs34325043 rs55933311 rs314665 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17962809}. Cell membrane {ECO:0000250|UniProtKB:Q15139}. Nucleus {ECO:0000269|PubMed:17962809}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:18262756}. Note=Translocation to the cell membrane is required for kinase activation. Accumulates in the nucleus upon CK1-mediated phosphorylation after activation of G-protein-coupled receptors. Nuclear accumulation is regulated by blocking nuclear export of active PRKD2 rather than by increasing import. {ECO:0000269|PubMed:17962809}. |
| Mouse PG classification | NA |
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