| Gene Information | |
|---|---|
| Gene Name | VSX2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 361 |
| Protein Names | Visual system homeobox 2 (Ceh-10 homeodomain-containing homolog) (Homeobox protein CHX10) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000119614 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P58304 |
| Gene Card | VSX2 |
| Uniprot ID | P58304 |
| Pfam | PF00046; PF03826 |
| In ASD | no |
| Allosteric Prediction | no (-0.960955456) |
| Ortholog in Animals | Alpaca_ VSX2 ( ortholog_one2one ) Dog_ VSX2 ( ortholog_one2one ) GuineaPig_ VSX2 ( ortholog_one2one ) Macaque_ VSX2 ( ortholog_one2one ) Mouse_ Vsx2 ( ortholog_one2one ) Pig_ VSX2 ( ortholog_one2one ) Rat_ Vsx2 ( ortholog_one2one ) Rabbit_ VSX2 ( ortholog_one2one ) |
| Ohnologs | VSX1 |
| Paralogs | ARGFX, PAX7, PAX3, ALX4, PAX2, UNCX, RAX2, PAX8, DMBX1, DPRX, PAX5, ISX, ALX3, RHOXF2B, RHOXF2, GSC2, SEBOX, RAX, DRGX, ARX, RHOXF1, PITX3, PRRX1, SHOX, SHOX2, PRRX2, OTX2, PAX4, EVX1, PAX1, PITX2, PHOX2A, CRX, PHOX2B, EVX2, ALX1, MIXL1, DUXA, PAX6, OTP, HESX1, NOBOX, PROP1, PAX9, GSC, ESX1, DUXB, DUX4, PITX1, OTX1 |
| Tissue | NA |
| Tissue Specificity | Abundantly expressed in retinal neuroblasts during eye development and in the inner nuclear layer of the adult retina. Within this layer, expression is stronger in the outer margin where bipolar cells predominate. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35214083 rs121912543 rs121912543 rs755799430 rs121912545 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q61412}. |
| Mouse PG classification | HPG |
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