| Gene Information | |
|---|---|
| Gene Name | VSX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 365 |
| Protein Names | Visual system homeobox 1 (Homeodomain protein RINX) (Retinal inner nuclear layer homeobox protein) (Transcription factor VSX1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000100987 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9NZR4 |
| Gene Card | VSX1 |
| Uniprot ID | Q9NZR4 |
| Pfam | PF00046 |
| In ASD | no |
| Allosteric Prediction | no (-0.883310765) |
| Ortholog in Animals | Alpaca_ VSX1 ( ortholog_one2one ) Dog_ VSX1 ( ortholog_one2one ) GuineaPig_ VSX1 ( ortholog_one2one ) Macaque_ VSX1 ( ortholog_one2one ) Mouse_ Vsx1 ( ortholog_one2one ) Pig_ VSX1 ( ortholog_one2one ) Rat_ Vsx1 ( ortholog_one2one ) |
| Ohnologs | VSX2 |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | In the adult eye, expressed in lens, iris, ciliary body, choroid, optical nerve head and, most strongly, in retina, but not expressed in sclera and cornea. According to PubMed:11978762, expressed in adult retina but not in lens and cornea. Within adult retina, found exclusively in the inner nuclear layer. Isoform 1, isoform 2, isoform 3 and isoform 4 expressed in adult retina, but not in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. Not expressed in thymus and spleen. Expressed in embryonic craniofacial tissue. Expressed in fetal (week 14) retina. Strongly expressed in neonatal retina, weakly in neonatal lens, choroid and cornea (day 1, 4; month 9). {ECO:0000269|PubMed:10673340, ECO:0000269|PubMed:10903837, ECO:0000269|PubMed:11978762, ECO:0000269|PubMed:18253095}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs74315436 rs6050307 rs140122268 rs74315434 rs74315433 rs74315432 rs771561481 rs749663315 rs148957473 rs576300014 rs74315435 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q91V10}. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |