| Gene Information | |
|---|---|
| Gene Name | VSTM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 236 |
| Protein Names | V-set and transmembrane domain-containing protein 1 (Signal inhibitory receptor on leukocytes-1) (SIRL-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000189068 ) 3 ( ENSG00000274887 ) 3 ( ENSG00000274953 ) 3 ( ENSG00000275330 ) 3 ( ENSG00000275577 ) 3 ( ENSG00000275962 ) 3 ( ENSG00000276066 ) 3 ( ENSG00000276159 ) 3 ( ENSG00000276363 ) 3 ( ENSG00000277607 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q6UX27 |
| Gene Card | VSTM1 |
| Uniprot ID | Q6UX27 |
| Pfam | PF13895 |
| In ASD | no |
| Allosteric Prediction | no (-1.566761595) |
| Ortholog in Animals | Alpaca_ VSTM1 ( ortholog_one2many ) Dog_ VSTM1 ( ortholog_one2one ) Macaque_ VSTM1 ( ortholog_one2one ) Pig_ VSTM1 ( ortholog_one2one ) Rat_ Vstm1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TARM1, IGSF1, LAIR2, A1BG, OSCAR, KIR2DL3, KIR3DL3, GP6, KIR3DL2, LILRB2, KIR3DL1, KIR2DS4, LILRB5, KIR2DL4, LILRA2, LILRA4, LILRA6, LILRA5, NCR1, LILRB4, LILRB1, FCAR, LILRA1, LILRB3, KIR2DL1 |
| Tissue | bone.marrow, whole.blood |
| Tissue Specificity | Expressed on myeloid (neutrophils, eosinophils and monocytes) but not on lymphoid cells. {ECO:0000269|PubMed:20375307}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2433724 |
| Subcellular location [CC] | [Isoform 1]: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.; [Isoform 2]: Secreted {ECO:0000269|PubMed:22960280}. |
| Mouse PG classification | NA |
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