Gene Information
Gene NameHBO1
OrganismHomo sapiens (Human)
Gene Length611
Protein NamesHistone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBO95251
Gene CardKAT7
Uniprot IDO95251
PfamPF01853; PF01530; PF17772
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityUbiquitously expressed, with highest levels in testis. {ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:10930412}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5GK9  (X-ray  2.40A  )  6MAJ  (X-ray  2.14A  )  6MAK  (X-ray  2.13A  )  7D0O  (X-ray  2.51A  )  7D0P  (X-ray  1.80A  )  7D0Q  (X-ray  2.21A  )  7D0R  (X-ray  1.95A  )  7D0S  (X-ray  2.30A  ) 
DBSNP NA 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:10930412, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:28719581}. Chromosome {ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:28719581}. Chromosome, centromere {ECO:0000269|PubMed:27270040}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5SVQ0}. Note=Associates with replication origins specifically during the G1 phase of the cell cycle (PubMed:18832067, PubMed:20129055). Localizes to transcription start sites (PubMed:21753189, PubMed:24065767). Localizes to ultraviolet-induced DNA damage sites following phosphorylation by ATR (PubMed:28719581). Localizes to centromeres in G1 phase (PubMed:27270040). {ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581}.
Mouse PG classificationNA
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