| Gene Information | |
|---|---|
| Gene Name | VPS53 |
| Organism | Homo sapiens (Human) |
| Gene Length | 832 |
| Protein Names | Vacuolar protein sorting-associated protein 53 homolog |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000141252 ) 3 ( ENSG00000283883 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q5VIR6 |
| Gene Card | VPS53 |
| Uniprot ID | Q5VIR6 |
| Pfam | PF04100 |
| In ASD | no |
| Allosteric Prediction | no (-1.307857399) |
| Ortholog in Animals | Alpaca_ VPS53 ( ortholog_one2one ) Dog_ VPS53 ( ortholog_one2one ) GuineaPig_ VPS53 ( ortholog_one2one ) Macaque_ VPS53 ( ortholog_one2one ) Mouse_ Vps53 ( ortholog_one2one ) Pig_ VPS53 ( ortholog_one2one ) Rat_ Vps53 ( ortholog_one2one ) Rabbit_ VPS53 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs16954056 rs61644407 rs587777465 |
| Subcellular location [CC] | Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15878329, ECO:0000269|PubMed:18367545}; Peripheral membrane protein. Endosome membrane {ECO:0000269|PubMed:18367545}; Peripheral membrane protein. Recycling endosome {ECO:0000269|PubMed:25799061}. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex (PubMed:25799061). {ECO:0000269|PubMed:25799061}. |
| Mouse PG classification | LPG |
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