| Gene Information | |
|---|---|
| Gene Name | VPS4B |
| Organism | Homo sapiens (Human) |
| Gene Length | 444 |
| Protein Names | Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000119541 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | O75351 |
| Gene Card | VPS4B |
| Uniprot ID | O75351 |
| Pfam | PF00004; PF17862; PF04212; PF09336 |
| In ASD | no |
| Allosteric Prediction | no (-0.167023142) |
| Ortholog in Animals | Alpaca_ VPS4B ( ortholog_one2one ) Dog_ VPS4B ( ortholog_one2one ) GuineaPig_ VPS4B ( ortholog_one2one ) Macaque_ VPS4B ( ortholog_one2one ) Mouse_ Vps4b ( ortholog_one2one ) Pig_ VPS4B ( ortholog_one2one ) Rat_ Vps4b ( ortholog_one2one ) Rabbit_ VPS4B ( ortholog_one2one ) |
| Ohnologs | VPS4A |
| Paralogs | FIGNL2, VPS4A, FIGN, ATAD1, FIGNL1, KATNAL2, SPAST, KATNAL1, KATNA1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:11563910}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.257142(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1WR0 (NMR - ) 1XWI (X-ray 2.80A ) 2CPT (NMR - ) 2JQH (NMR - ) 2JQK (NMR - ) 4U7Y (X-ray 2.50A ) 7L9X (X-ray 2.81A ) |
| DBSNP | rs17688948 |
| Subcellular location [CC] | Late endosome membrane {ECO:0000250|UniProtKB:P46467}; Peripheral membrane protein {ECO:0000305}. Note=Membrane-associated in the prevacuolar endosomal compartment. Localized in HIV-1 particles purified from acutely infected cells. {ECO:0000269|PubMed:14505570}. |
| Mouse PG classification | NA |
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