| Gene Information | |
|---|---|
| Gene Name | VPS4A |
| Organism | Homo sapiens (Human) |
| Gene Length | 437 |
| Protein Names | Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6) (Protein SKD2) (VPS4-1) (hVPS4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000132612 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | Q9UN37 |
| Gene Card | VPS4A |
| Uniprot ID | Q9UN37 |
| Pfam | PF00004; PF17862; PF04212; PF09336 |
| In ASD | no |
| Allosteric Prediction | no (-0.4118358) |
| Ortholog in Animals | Alpaca_ VPS4A ( ortholog_one2one ) Dog_ VPS4A ( ortholog_one2one ) GuineaPig_ VPS4A ( ortholog_one2one ) Mouse_ Vps4a ( ortholog_one2one ) Pig_ VPS4A ( ortholog_one2one ) Rat_ Vps4a ( ortholog_one2one ) |
| Ohnologs | VPS4B |
| Paralogs | FIGNL2, FIGN, ATAD1, FIGNL1, KATNAL2, SPAST, VPS4B, KATNAL1, KATNA1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:10637304, ECO:0000269|PubMed:11563910}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001942(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1YXR (NMR - ) 2JQ9 (NMR - ) 2K3W (NMR - ) |
| DBSNP | rs1965431981 rs1965484288 |
| Subcellular location [CC] | Late endosome membrane {ECO:0000250|UniProtKB:Q8VEJ9}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8VEJ9}. Midbody {ECO:0000269|PubMed:24814515}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:33186543}. Note=Membrane-associated in the prevacuolar endosomal compartment. Localizes to the midbody of dividing cells, interaction with ZFYVE19/ANCHR mediates retention at midbody (PubMed:24814515). Localized in two distinct rings on either side of the Flemming body. {ECO:0000269|PubMed:24814515}. |
| Mouse PG classification | NA |
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