| Gene Information | |
|---|---|
| Gene Name | SYN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 705 |
| Protein Names | Synapsin-1 (Brain protein 4.1) (Synapsin I) |
| Target Name | synapsin-1 |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000008056 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P17600 |
| Gene Card | SYN1 |
| Uniprot ID | P17600 |
| Pfam | PF02078; PF02750; PF10581 |
| In ASD | no |
| Allosteric Prediction | yes (0.708474033) |
| Ortholog in Animals | Alpaca_ SYN1 ( ortholog_one2one ) Dog_ SYN1 ( ortholog_one2one ) GuineaPig_ SYN1 ( ortholog_one2one ) Macaque_ SYN1 ( ortholog_one2one ) Mouse_ Syn1 ( ortholog_one2one ) Pig_ SYN1 ( ortholog_one2one ) Rat_ Syn1 ( ortholog_one2one ) Rabbit_ SYN1 ( ortholog_one2one ) |
| Ohnologs | SYN2, SYN3 |
| Paralogs | SYN3, SYN2 |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2057941303 rs397514680 rs200533370 |
| Subcellular location [CC] | Synapse {ECO:0000250|UniProtKB:O88935}. Golgi apparatus {ECO:0000250|UniProtKB:O88935}. Presynapse {ECO:0000269|PubMed:21441247}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:P09951}. Note=Dissociates from synaptic vesicles and redistributes into the axon during action potential firing, in a step that precedes fusion of vesicles with the plasma membrane. Reclusters to presynapses after the cessation of synaptic activity. {ECO:0000250|UniProtKB:P09951}. |
| Mouse PG classification | NA |
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