| Gene Information | |
|---|---|
| Gene Name | VPS37A |
| Organism | Homo sapiens (Human) |
| Gene Length | 397 |
| Protein Names | Vacuolar protein sorting-associated protein 37A (hVps37A) (ESCRT-I complex subunit VPS37A) (Hepatocellular carcinoma-related protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000155975 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8NEZ2 |
| Gene Card | VPS37A |
| Uniprot ID | Q8NEZ2 |
| Pfam | PF07200 |
| In ASD | no |
| Allosteric Prediction | no (-0.688475849) |
| Ortholog in Animals | Alpaca_ VPS37A ( ortholog_one2one ) Dog_ VPS37A ( ortholog_one2one ) GuineaPig_ VPS37A ( ortholog_one2one ) Macaque_ VPS37A ( ortholog_one2one ) Mouse_ Vps37a ( ortholog_one2one ) Pig_ VPS37A ( ortholog_one2one ) Rat_ Vps37a ( ortholog_one2one ) Rabbit_ VPS37A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VPS37D, VPS37C, VPS37B |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Examined tissues include heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. More abundant in liver. Strongly decreased or undetected in hepatomas. {ECO:0000269|PubMed:14623289, ECO:0000269|PubMed:22717650}. |
| Pharmacological Animal Models | 0.252347(Chimpanzee);0.215036(Mouse);0.003490(Rat);0.054545(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17502618 rs17687375 rs211694394 |
| Subcellular location [CC] | Late endosome membrane; Peripheral membrane protein. Nucleus. |
| Mouse PG classification | NA |
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