| Gene Information | |
|---|---|
| Gene Name | VPS34 |
| Organism | Homo sapiens (Human) |
| Gene Length | 887 |
| Protein Names | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8NEB9 |
| Gene Card | PIK3C3 |
| Uniprot ID | Q8NEB9 |
| Pfam | PF00454; PF00792; PF00613 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, with a highest expression in skeletal muscle. {ECO:0000269|PubMed:7628435}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.032468(Mouse);0.003717(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3IHY (X-ray 2.80A ) 3LS8 (X-ray 2.25A ) 4OYS (X-ray 2.90A ) 4PH4 (X-ray 2.80A ) 4UWF (X-ray 2.99A ) 4UWG (X-ray 2.70A ) 4UWH (X-ray 1.93A ) 4UWK (X-ray 2.83A ) 4UWL (X-ray 2.80A ) 5ANL (X-ray 2.70A ) 5ENN (X-ray 2.70A ) 6HOH (X-ray 2.25A ) 6I3U (X-ray 2.09A ) 6YKG (X-ray 3.12A ) 7BL1 (EM 9.80A ) 7RSJ (X-ray 1.88A ) 7RSP (X-ray 1.67A ) 7RSV (X-ray 1.78A ) |
| DBSNP | NA |
| Subcellular location [CC] | Midbody {ECO:0000269|PubMed:20208530}. Late endosome {ECO:0000269|PubMed:14617358}. Cytoplasmic vesicle, autophagosome {ECO:0000305|PubMed:14617358}. Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:Q6PF93, ECO:0000305|PubMed:14617358}. |
| Mouse PG classification | NA |
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