| Gene Information | |
|---|---|
| Gene Name | VPS33B |
| Organism | Homo sapiens (Human) |
| Gene Length | 617 |
| Protein Names | Vacuolar protein sorting-associated protein 33B (hVPS33B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000184056 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H267 |
| Gene Card | VPS33B |
| Uniprot ID | Q9H267 |
| Pfam | PF00995 |
| In ASD | no |
| Allosteric Prediction | no (-1.053896904) |
| Ortholog in Animals | Alpaca_ VPS33B ( ortholog_one2one ) Dog_ VPS33B ( ortholog_one2one ) GuineaPig_ VPS33B ( ortholog_one2one ) Mouse_ Vps33b ( ortholog_one2one ) Pig_ VPS33B ( ortholog_one2one ) Rat_ Vps33b ( ortholog_one2one ) Rabbit_ VPS33B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SCFD2, VPS33A, STXBP3, STXBP2, SCFD1, STXBP1, VPS45 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous; highly expressed in testis and low expression in the lung. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001823(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs121434385 rs139829189 rs3177428 rs11073964 |
| Subcellular location [CC] | Late endosome membrane {ECO:0000269|PubMed:15052268}; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane {ECO:0000269|PubMed:15052268}; Peripheral membrane protein; Cytoplasmic side. Early endosome {ECO:0000269|PubMed:21411634}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:21411634}. Recycling endosome {ECO:0000269|PubMed:22753090}. Note=Colocalizes in clusters with VIPAS39 at cytoplasmic organelles (PubMed:19109425). Colocalizes with RAB11A and VIPAS39 on recycling endosomes (PubMed:22753090). Colocalizes with AP-3, clathrin, Rab5 and Rab7b (PubMed:21411634). Colocalizes with M.tuberculosis PtpA in the cytosol of tuberculosis-infected macrophages and associates with phagosomes (PubMed:18474358). {ECO:0000269|PubMed:18474358, ECO:0000269|PubMed:19109425, ECO:0000269|PubMed:21411634, ECO:0000269|PubMed:22753090}. |
| Mouse PG classification | LPG |
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