| Gene Information | |
|---|---|
| Gene Name | VPS41 |
| Organism | Homo sapiens (Human) |
| Gene Length | 854 |
| Protein Names | Vacuolar protein sorting-associated protein 41 homolog (S53) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000006715 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P49754 |
| Gene Card | VPS41 |
| Uniprot ID | P49754 |
| Pfam | PF00637 |
| In ASD | no |
| Allosteric Prediction | no (-1.044532399) |
| Ortholog in Animals | Alpaca_ VPS41 ( ortholog_one2one ) Dog_ VPS41 ( ortholog_one2one ) GuineaPig_ VPS41 ( ortholog_one2one ) Macaque_ VPS41 ( ortholog_one2one ) Mouse_ Vps41 ( ortholog_one2one ) Pig_ VPS41 ( ortholog_one2one ) Rat_ Vps41 ( ortholog_one2one ) Rabbit_ VPS41 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in cerebral cortex and cerebellum. Highly expressed in Purkinje cells. {ECO:0000269|PubMed:33764426}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.249840(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35693565 rs544223875 rs11762417 rs1059508 |
| Subcellular location [CC] | Endosome membrane {ECO:0000269|PubMed:21411634, ECO:0000269|PubMed:23322049, ECO:0000269|PubMed:25445562}; Peripheral membrane protein {ECO:0000269|PubMed:23167963, ECO:0000269|PubMed:25445562}. Late endosome membrane {ECO:0000269|PubMed:23322049, ECO:0000269|PubMed:33422265}; Peripheral membrane protein {ECO:0000269|PubMed:23167963, ECO:0000269|PubMed:25445562}. Early endosome membrane {ECO:0000269|PubMed:21411634}; Peripheral membrane protein {ECO:0000269|PubMed:23167963, ECO:0000269|PubMed:25445562}. Lysosome membrane {ECO:0000269|PubMed:21802320, ECO:0000269|PubMed:23322049, ECO:0000269|PubMed:33422265, ECO:0000269|PubMed:33851776}; Peripheral membrane protein {ECO:0000269|PubMed:23167963}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:23322049}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:21411634}. Cytoplasm, cytosol {ECO:0000269|PubMed:23167963}.; Note=(Microbial infection) Sequestrated at the late endosome by SARS coronavirus-2/SARS-CoV-2 ORF3A protein. {ECO:0000269|PubMed:33422265}. |
| Mouse PG classification | NA |
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