| Gene Information | |
|---|---|
| Gene Name | VPS11 |
| Organism | Homo sapiens (Human) |
| Gene Length | 941 |
| Protein Names | Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000160695 ) 3 ( ENSG00000280616 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H270 |
| Gene Card | VPS11 |
| Uniprot ID | Q9H270 |
| Pfam | PF00637; PF12451 |
| In ASD | no |
| Allosteric Prediction | no (-0.825457951) |
| Ortholog in Animals | Alpaca_ VPS11 ( ortholog_one2one ) Dog_ VPS11 ( ortholog_one2one ) GuineaPig_ VPS11 ( ortholog_one2one ) Macaque_ VPS11 ( ortholog_one2one ) Mouse_ Vps11 ( ortholog_one2one ) Pig_ VPS11 ( ortholog_one2one ) Rat_ Vps11 ( ortholog_one2one ) Rabbit_ VPS11 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VPS18 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Expression was highest in heart and low in lung. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11558589 |
| Subcellular location [CC] | Endosome {ECO:0000269|PubMed:20682791}. Late endosome membrane {ECO:0000269|PubMed:11382755, ECO:0000269|PubMed:21148287}; Peripheral membrane protein {ECO:0000269|PubMed:11382755}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:11382755, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:21802320}; Peripheral membrane protein {ECO:0000269|PubMed:11382755}; Cytoplasmic side {ECO:0000305}. Early endosome {ECO:0000269|PubMed:21148287, ECO:0000305}. Cytoplasmic vesicle {ECO:0000305}. Cytoplasmic vesicle, autophagosome {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000305}. |
| Mouse PG classification | NA |
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