| Gene Information | |
|---|---|
| Gene Name | VPO |
| Organism | Homo sapiens (Human) |
| Gene Length | 1479 |
| Protein Names | Peroxidasin homolog (EC 1.11.2.-) (Melanoma-associated antigen MG50) (Peroxidasin 1) (hsPxd01) (Vascular peroxidase 1) (p53-responsive gene 2 protein) [Cleaved into: PXDN active fragment] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q92626 |
| Gene Card | PXDN |
| Uniprot ID | Q92626 |
| Pfam | PF03098; PF07679; PF13855; PF00093 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at higher levels in heart, lung, ovary, spleen, intestine and placenta, and at lower levels in liver, colon, pancreas, kidney, thymus, skeletal muscle and prostate. Expressed in tumors such as melanoma, breast cancer, ovarian cancer and glioblastoma. A shorter form probably lacking the signal sequence is found in testis and in EB1 cells undergoing p53/TP53-dependent apoptosis. {ECO:0000269|PubMed:10441517, ECO:0000269|PubMed:11103812, ECO:0000269|PubMed:18929642, ECO:0000269|PubMed:19590037}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs587777572 rs6723697 rs6723697 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:18929642, ECO:0000269|PubMed:19590037, ECO:0000269|PubMed:26178375, ECO:0000269|Ref.9}. Endoplasmic reticulum {ECO:0000269|PubMed:19590037, ECO:0000269|PubMed:25708780}. Cell surface {ECO:0000269|PubMed:25708780}. Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250|UniProtKB:Q3UQ28}. Note=Enriched in the peritubular space of fibrotic kidneys. Adheres on the cell surface in 'hot spots' (PubMed:25708780). Only the proteolytically processed PXDN integrates into the extracellular matrix (PubMed:34679700). {ECO:0000269|PubMed:25708780, ECO:0000269|PubMed:34679700}.; [PXDN active fragment]: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:34679700}. |
| Mouse PG classification | NA |
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