| Gene Information | |
|---|---|
| Gene Name | CLCN7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 805 |
| Protein Names | H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000103249 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P51798 |
| Gene Card | CLCN7 |
| Uniprot ID | P51798 |
| Pfam | PF00571; PF00654 |
| In ASD | no |
| Allosteric Prediction | no (-0.518938436) |
| Ortholog in Animals | Alpaca_ CLCN7 ( ortholog_one2one ) Dog_ CLCN7 ( ortholog_one2one ) GuineaPig_ CLCN7 ( ortholog_one2one ) Macaque_ CLCN7 ( ortholog_one2one ) Mouse_ Clcn7 ( ortholog_one2one ) Pig_ CLCN7 ( ortholog_one2one ) Rat_ Clcn7 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CLCN6, CLCN3, CLCN5, CLCNKB, CLCNKA, CLCN1, CLCN4, CLCN2 |
| Tissue | NA |
| Tissue Specificity | Brain and kidney. {ECO:0000269|PubMed:31155284}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7BXU (EM 3.70A ) 7CQ5 (EM 2.60A ) 7CQ6 (EM 3.00A ) 7CQ7 (EM 3.55A ) 7JM7 (EM 2.82A ) |
| DBSNP | rs367567630 rs397515539 rs760209068 rs1360480518 rs121434436 rs760956030 rs1291061962 rs977932714 rs2038825509 rs765444328 rs12926089 rs368190250 rs139329533 rs1233085260 rs1064794323 rs1057517718 rs1320932332 rs760740877 rs121434433 rs1490598538 rs121434434 rs772579858 rs121434435 |
| Subcellular location [CC] | Lysosome membrane {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911}; Multi-pass membrane protein {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911}. |
| Mouse PG classification | NA |
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