| Gene Information | |
|---|---|
| Gene Name | EFNB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 333 |
| Protein Names | Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000125266 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P52799 |
| Gene Card | EFNB2 |
| Uniprot ID | P52799 |
| Pfam | PF00812 |
| In ASD | no |
| Allosteric Prediction | yes (0.171916717) |
| Ortholog in Animals | Alpaca_ EFNB2 ( ortholog_one2one ) Dog_ EFNB2 ( ortholog_one2one ) GuineaPig_ EFNB2 ( ortholog_one2one ) Macaque_ EFNB2 ( ortholog_one2one ) Mouse_ Efnb2 ( ortholog_one2one ) Pig_ EFNB2 ( ortholog_one2one ) Rat_ Efnb2 ( ortholog_one2one ) Rabbit_ EFNB2 ( ortholog_one2one ) |
| Ohnologs | EFNB1, EFNB3 |
| Paralogs | EFNA2, EFNB3, EFNB1, EFNA1, EFNA3, EFNA4, EFNA5 |
| Tissue | NA |
| Tissue Specificity | Lung and kidney. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2HLE (X-ray 2.05A ) 2I85 (NMR - ) 2VSK (X-ray 3.30A ) 2VSM (X-ray 1.80A ) 2WO2 (X-ray 2.45A ) 3GXU (X-ray 2.50A ) 4UF7 (X-ray 1.70A ) 6P7Y (X-ray 2.84A ) 6PDL (X-ray 2.70A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:28931592}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P52800}. |
| Mouse PG classification | NA |
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