| Gene Information | |
|---|---|
| Gene Name | PDCD6IP |
| Organism | Homo sapiens (Human) |
| Gene Length | 868 |
| Protein Names | Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000170248 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8WUM4 |
| Gene Card | PDCD6IP |
| Uniprot ID | Q8WUM4 |
| Pfam | PF13949; PF03097 |
| In ASD | no |
| Allosteric Prediction | no (-0.078652697) |
| Ortholog in Animals | Alpaca_ PDCD6IP ( ortholog_one2one ) GuineaPig_ PDCD6IP ( ortholog_one2one ) Macaque_ PDCD6IP ( ortholog_one2one ) Pig_ PDCD6IP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.009241(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2OEV (X-ray 3.30A ) 2OEW (X-ray 2.55A ) 2OEX (X-ray 2.58A ) 2OJQ (X-ray 2.87A ) 2R02 (X-ray 2.60A ) 2R03 (X-ray 2.59A ) 2R05 (X-ray 2.55A ) 2XS1 (X-ray 2.30A ) 2XS8 (X-ray 2.50A ) 2ZNE (X-ray 2.20A ) 3C3O (X-ray 2.15A ) 3C3Q (X-ray 2.10A ) 3C3R (X-ray 2.02A ) 3E1R (X-ray 2.00A ) 3WUV (X-ray 2.79A ) 4JJY (X-ray 6.50A ) 5V3R (X-ray 1.91A ) 5WA1 (X-ray 1.87A ) 6KP3 (X-ray 2.20A ) |
| DBSNP | rs11554560 rs3792594 rs3203777 rs76608858 rs9813017 rs3183982 rs1127732 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9QZA2}. Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893}. Secreted, extracellular exosome {ECO:0000269|PubMed:22660413}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9WU78}. Midbody, Midbody ring {ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Colocalized with CEP55 at centrosomes of non-dividing cells. Component of the actomyosin-tight junction complex (By similarity). PDCD6IP targeting to the midbody requires the interaction with CEP55 (PubMed:18641129). {ECO:0000250|UniProtKB:Q9QZA2, ECO:0000250|UniProtKB:Q9WU78, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129}. |
| Mouse PG classification | NA |
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