| Gene Information | |
|---|---|
| Gene Name | VKORC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 163 |
| Protein Names | Vitamin K epoxide reductase complex subunit 1 (EC 1.17.4.4) (Vitamin K1 2,3-epoxide reductase subunit 1) |
| Target Name | vitamin k epoxide reductase complex 1 |
| Target Type | Successful target |
| Gene Age | 987 ( ENSG00000167397 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BQB6 |
| Gene Card | VKORC1 |
| Uniprot ID | Q9BQB6 |
| Pfam | PF07884 |
| In ASD | no |
| Allosteric Prediction | no (-0.164764013) |
| Ortholog in Animals | Alpaca_ VKORC1 ( ortholog_one2one ) Dog_ VKORC1 ( ortholog_one2one ) GuineaPig_ VKORC1 ( ortholog_one2one ) Mouse_ Vkorc1 ( ortholog_one2one ) Pig_ VKORC1 ( ortholog_one2one ) Rat_ Vkorc1 ( ortholog_one2one ) Rabbit_ VKORC1 ( ortholog_one2one ) |
| Ohnologs | VKORC1L1 |
| Paralogs | VKORC1L1 |
| Tissue | NA |
| Tissue Specificity | Expressed at highest levels in fetal and adult liver, followed by fetal heart, kidney, and lung, adult heart, and pancreas. {ECO:0000269|PubMed:14765194}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6WV3 (X-ray 2.20A ) 6WV4 (X-ray 3.01A ) 6WV5 (X-ray 2.80A ) 6WV6 (X-ray 2.70A ) 6WV7 (X-ray 2.48A ) 6WVH (X-ray 1.99A ) |
| DBSNP | rs770703948 rs104894539 rs61742245 rs104894540 rs104894541 rs72547529 rs755767348 rs72547528 rs104894542 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:15716279, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}; Multi-pass membrane protein {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:15716279, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20696932, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610, ECO:0000269|PubMed:33154105}. |
| Mouse PG classification | NA |
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