| Gene Information | |
|---|---|
| Gene Name | VISA |
| Organism | Homo sapiens (Human) |
| Gene Length | 540 |
| Protein Names | Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q7Z434 |
| Gene Card | MAVS |
| Uniprot ID | Q7Z434 |
| Pfam | PF16739 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes. {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.007254(Mouse);NULL(Rat);0.129839(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2MS7 (NMR - ) 2MS8 (NMR - ) 2VGQ (X-ray 2.10A ) 3J6C (EM 9.60A ) 3J6J (EM 3.64A ) 3RC5 (X-ray 1.60A ) 4P4H (X-ray 3.40A ) 4Z8M (X-ray 2.95A ) 5JEK (X-ray 2.40A ) 7DNI (EM 3.20A ) |
| DBSNP | rs11905552 rs11908032 rs17857295 rs7262903 rs7269320 |
| Subcellular location [CC] | Mitochondrion outer membrane {ECO:0000269|PubMed:16125763}. Mitochondrion {ECO:0000269|PubMed:11780052, ECO:0000269|PubMed:17709747, ECO:0000269|PubMed:20127681, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:21170385, ECO:0000269|PubMed:25135833, ECO:0000269|PubMed:27736772}. Peroxisome {ECO:0000269|PubMed:20451243}. |
| Mouse PG classification | NA |
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