| Gene Information | |
|---|---|
| Gene Name | VIPR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 438 |
| Protein Names | Vasoactive intestinal polypeptide receptor 2 (VIP-R-2) (Helodermin-preferring VIP receptor) (Pituitary adenylate cyclase-activating polypeptide type III receptor) (PACAP type III receptor) (PACAP-R-3) (PACAP-R3) (VPAC2) |
| Target Name | helodermin-preferring vip receptor |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000106018 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P41587 |
| Gene Card | VIPR2 |
| Uniprot ID | P41587 |
| Pfam | PF00002; PF02793 |
| In ASD | no |
| Allosteric Prediction | yes (0.58362079) |
| Ortholog in Animals | Alpaca_ VIPR2 ( ortholog_one2one ) Dog_ VIPR2 ( ortholog_one2one ) GuineaPig_ Vipr2 ( ortholog_one2one ) Macaque_ VIPR2 ( ortholog_one2one ) Mouse_ Vipr2 ( ortholog_one2one ) Pig_ VIPR2 ( ortholog_one2one ) Rat_ Vipr2 ( ortholog_one2one ) Rabbit_ VIPR2 ( ortholog_one2one ) |
| Ohnologs | GLP2R, CRHR1, SCTR, VIPR1, PTH2R |
| Paralogs | ADGRE3, ADGRL2, VIPR1, ADGRL4, ADGRE2, ADGRG4, ADGRD1, ADGRL3, GHRHR, PTH2R, ADGRE1, ADGRD2, ADGRL1, ADGRB3, EVA1C, ADGRG1, SCTR, ADGRF5, ADGRA3, GLP2R, PTH1R, CALCR, ADGRF3, GIPR, ADGRA1, ADGRF1, ADCYAP1R1, ADGRG5, ADGRE5, CRHR2, ADGRB2, ADGRG6, GCGR, ADGRB1, ADGRG2, ADGRA2, ADGRF4, ADGRG7, CALCRL, ADGRG3, CRHR1, GLP1R |
| Tissue | NA |
| Tissue Specificity | Expressed in CD4+ T-cells, but not in CD8+ T-cells. Expressed in the T-cell lines Jurkat, Peer, MOLT-4, HSB, YT and SUP-T1, but not in the T-cell lines HARRIS and HuT 78. {ECO:0000269|PubMed:8926282}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2X57 (X-ray 2.10A ) 7VQX (EM 2.74A ) 7WBJ (EM 3.42A ) |
| DBSNP | rs1062609 rs1042620 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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