| Gene Information | |
|---|---|
| Gene Name | VIM |
| Organism | Homo sapiens (Human) |
| Gene Length | 466 |
| Protein Names | Vimentin |
| Target Name | vimentin |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000026025 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P08670 |
| Gene Card | VIM |
| Uniprot ID | P08670 |
| Pfam | PF00038; PF04732 |
| In ASD | no |
| Allosteric Prediction | yes (1.178295834) |
| Ortholog in Animals | Alpaca_ VIM ( ortholog_one2one ) Dog_ VIM ( ortholog_one2many ) GuineaPig_ VIM ( ortholog_one2one ) Macaque_ VIM ( ortholog_one2one ) Mouse_ Vim ( ortholog_one2one ) Pig_ VIM ( ortholog_one2one ) Rat_ Vim ( ortholog_one2one ) Rabbit_ VIM ( ortholog_one2one ) |
| Ohnologs | KRT33A, KRT18, GFAP, PRPH, KRT7, INA, KRT84, KRT82, KRT80, KRT1, KRT8, KRT86, KRT75, KRT6C, KRT4, KRT83, KRT19, KRT15, KRT2, KRT6B, KRT79, KRT5, KRT10, KRT17P2, KRT16, KRT14, KRT77, KRT6A, NEFM, DES |
| Paralogs | KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT17, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines. {ECO:0000269|PubMed:2472876, ECO:0000269|PubMed:3371665}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001253(Rat);0.021053(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1GK4 (X-ray 2.30A ) 1GK6 (X-ray 1.90A ) 1GK7 (X-ray 1.40A ) 3G1E (X-ray 1.83A ) 3KLT (X-ray 2.70A ) 3S4R (X-ray 2.45A ) 3SSU (X-ray 2.60A ) 3SWK (X-ray 1.70A ) 3TRT (X-ray 2.30A ) 3UF1 (X-ray 2.81A ) 4MCY (X-ray 2.30A ) 4MCZ (X-ray 2.41A ) 4MD0 (X-ray 2.19A ) 4MD5 (X-ray 1.65A ) 4MDI (X-ray 2.00A ) 4MDJ (X-ray 1.70A ) 4YPC (X-ray 1.44A ) 4YV3 (X-ray 2.00A ) 5WHF (X-ray 2.25A ) 6ATF (X-ray 1.90A ) 6ATI (X-ray 1.98A ) 6BIR (X-ray 2.30A ) 6YXK (X-ray 2.00A ) |
| DBSNP | rs121917775 rs1085307141 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21465480, ECO:0000269|PubMed:29496907}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18408015, ECO:0000269|PubMed:29496907}. Nucleus matrix {ECO:0000250|UniProtKB:P31000}. Cell membrane {ECO:0000250|UniProtKB:P20152}. |
| Mouse PG classification | NA |
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