| Gene Information | |
|---|---|
| Gene Name | VIL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 827 |
| Protein Names | Villin-1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000127831 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P09327 |
| Gene Card | VIL1 |
| Uniprot ID | P09327 |
| Pfam | PF00626; PF02209 |
| In ASD | no |
| Allosteric Prediction | yes (0.034216059) |
| Ortholog in Animals | Alpaca_ VIL1 ( ortholog_one2one ) Dog_ VIL1 ( ortholog_one2one ) GuineaPig_ VIL1 ( ortholog_one2one ) Macaque_ VIL1 ( ortholog_one2one ) Mouse_ Vil1 ( ortholog_one2one ) Pig_ VIL1 ( ortholog_one2one ) Rat_ Vil1 ( ortholog_one2many ) Rabbit_ VIL1 ( ortholog_one2one ) |
| Ohnologs | SCIN, AVIL, VILL, GSN |
| Paralogs | VILL, SCIN, SVIL, CAPG, AVIL, FLII, GSN |
| Tissue | colon, duodenum, rectum, small.intestine, gall.bladder, small.intestine.Peyers.patch, transverse.colon |
| Tissue Specificity | Specifically expressed in epithelial cells. Major component of microvilli of intestinal epithelial cells and kidney proximal tubule cells. Expressed in canalicular microvilli of hepatocytes (at protein level). {ECO:0000269|PubMed:14550699, ECO:0000269|PubMed:3453110}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1UNC (NMR - ) 3FG7 (X-ray 2.00A ) |
| DBSNP | rs35305540 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cell projection, microvillus. Cell projection, filopodium tip {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Note=Relocalized in the tip of cellular protrusions and filipodial extensions upon infection with S.flexneri in primary intestinal epithelial cells (IEC) and in the tail-like structures forming the actin comets of S.flexneri. Redistributed to the leading edge of hepatocyte growth factor (HGF)-induced lamellipodia (By similarity). Rapidly redistributed to ruffles and lamellipodia structures in response to autotaxin, lysophosphatidic acid (LPA) and epidermal growth factor (EGF) treatment. {ECO:0000250}. |
| Mouse PG classification | NA |
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