Gene Information

Gene Information
Gene Name	VHL
Organism	Homo sapiens (Human)
Gene Length	213
Protein Names	von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL)
Target Name	von hippel-lindau disease tumor suppressor
Target Type	Patented-recorded target
Gene Age	55 ( ENSG00000134086 )
Evolutionary Stage	Eumetazoa
AlphaFoldDB	P40337
Gene Card	VHL
Uniprot ID	P40337
Pfam	PF01847; PF17211
In ASD	no
Allosteric Prediction	yes (0.229609446)
Ortholog in Animals	Alpaca_ VHL ( ortholog_one2one ) Macaque_ VHL ( ortholog_one2one ) Mouse_ Vhl ( ortholog_one2many ) Rat_ Vhl ( ortholog_one2many )
Ohnologs	NA
Paralogs	VHLL
Tissue	NA
Tissue Specificity	Expressed in the adult and fetal brain and kidney.
Pharmacological Animal Models	NULL(Chimpanzee);NULL(Mouse);0.157398(Rat);NULL(Rabbit)
Gene Ontology (biological process)
Gene Ontology (cellular component)
Gene Ontology (molecular function)
PDB	1LM8 (X-ray 1.85A ) 1LQB (X-ray 2.00A ) 1VCB (X-ray 2.70A ) 3ZRC (X-ray 2.90A ) 3ZRF (X-ray 2.80A ) 3ZTC (X-ray 2.65A ) 3ZTD (X-ray 2.79A ) 3ZUN (X-ray 2.50A ) 4AJY (X-ray 1.73A ) 4AWJ (X-ray 2.50A ) 4B95 (X-ray 2.80A ) 4B9K (X-ray 2.00A ) 4BKS (X-ray 2.20A ) 4BKT (X-ray 2.35A ) 4W9C (X-ray 2.20A ) 4W9D (X-ray 2.20A ) 4W9E (X-ray 2.60A ) 4W9F (X-ray 2.10A ) 4W9G (X-ray 2.70A ) 4W9H (X-ray 2.10A ) 4W9I (X-ray 2.40A ) 4W9J (X-ray 2.20A ) 4W9K (X-ray 2.10A ) 4W9L (X-ray 2.20A ) 4WQO (X-ray 3.20A ) 5LLI (X-ray 2.40A ) 5N4W (X-ray 3.90A ) 5NVV (X-ray 2.10A ) 5NVW (X-ray 2.20A ) 5NVX (X-ray 2.20A ) 5NVY (X-ray 2.90A ) 5NVZ (X-ray 2.70A ) 5NW0 (X-ray 2.30A ) 5NW1 (X-ray 2.10A ) 5NW2 (X-ray 2.20A ) 5T35 (X-ray 2.70A ) 6BVB (X-ray 2.00A ) 6FMI (X-ray 2.80A ) 6FMJ (X-ray 2.45A ) 6FMK (X-ray 2.75A ) 6GFX (X-ray 1.83A ) 6GFY (X-ray 2.70A ) 6GFZ (X-ray 2.30A ) 6GMN (X-ray 1.94A ) 6GMQ (X-ray 2.75A ) 6GMR (X-ray 1.75A ) 6GMX (X-ray 2.53A ) 6HAX (X-ray 2.35A ) 6HAY (X-ray 2.24A ) 6HR2 (X-ray 1.76A ) 6I7Q (X-ray 1.80A ) 6I7R (X-ray 1.95A ) 6R6H (EM 8.40A ) 6R7F (EM 8.20A ) 6SIS (X-ray 3.50A ) 6ZHC (X-ray 1.92A ) 7CJB (X-ray 2.80A ) 7JTO (X-ray 1.70A ) 7JTP (X-ray 2.12A ) 7KHH (X-ray 2.28A ) 7PI4 (X-ray 2.24A ) 7Q2J (X-ray 2.50A ) 7Z6L (X-ray 2.24A )
DBSNP	rs35460768 rs373068386 rs104893827 rs104893826 rs869025616 rs5030826 rs5030826 rs5030802 rs5030803 rs794729660 rs1559425911 rs730882033 rs869025621 rs5030804 rs5030804 rs5030805 rs5030805 rs786202787 rs104893829 rs794726890 rs5030827 rs398123481 rs730882034 rs730882034 rs398123481 rs1553619431 rs119103277 rs5030807 rs5030807 rs1060503563 rs5030808 rs1553619440 rs5030808 rs1559426089 rs5030809 rs869025630 rs1553619461 rs1446876735 rs397516440 rs193922609 rs17855706 rs1559426203 rs869025631 rs765978945 rs104893824 rs104893824 rs869025636 rs869025636 rs864622646 rs5030812 rs5030811 rs727504215 rs5030830 rs5030830 rs1553619948 rs5030832 rs104893831 rs1553619956 rs104893830 rs1064794272 rs119103278 rs5030833 rs5030833 rs773556807 rs771727849 rs1060503555 rs587780077 rs1399097617 rs869025659 rs397516441 rs869025660 rs121913346 rs1559429613 rs1575932011 rs5030818 rs730882035 rs397516444 rs1553620313 rs5030622 rs397516444 rs28940297 rs1352275281 rs267607170 rs397516445 rs104893825 rs5030820 rs5030821 rs5030820 rs864321642 rs5030822 rs5030822 rs377715747 rs1064793878 rs367545984 rs1559429813 rs1559429824 rs1559429824 rs5030824 rs28940301 rs28940300 rs28940298
Subcellular location [CC]	[Isoform 1]: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated. Colocalizes with ADRB2 at the cell membrane.; [Isoform 3]: Cytoplasm. Nucleus. Note=Equally distributed between the nucleus and the cytoplasm but not membrane-associated.
Mouse PG classification	NA
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