Gene Information
Gene NameMUC4
OrganismHomo sapiens (Human)
Gene Length5412
Protein NamesMucin-4 (MUC-4) (Ascites sialoglycoprotein) (ASGP) (Pancreatic adenocarcinoma mucin) (Testis mucin) (Tracheobronchial mucin) [Cleaved into: Mucin-4 alpha chain (Ascites sialoglycoprotein 1) (ASGP-1); Mucin-4 beta chain (Ascites sialoglycoprotein 2) (ASGP-2)]
Target NameNA
Target TypeNA
Gene Age680 ( ENSG00000145113 )
3 ( ENSG00000273822 )
3 ( ENSG00000273984 )
3 ( ENSG00000276613 )
3 ( ENSG00000277585 )
3 ( ENSG00000278303 )
3 ( ENSG00000278468 )
Evolutionary StageVertebrata
AlphaFoldDBQ99102
Gene CardMUC4
Uniprot IDQ99102
PfamPF06119; PF00094
In ASDno
Allosteric Predictionno (-0.557873831)
Ortholog in AnimalsMouse_ Muc4 ( ortholog_one2one )
OhnologsNA
ParalogsRTL9, SUSD2
Tissuecolon, rectum, transverse.colon
Tissue SpecificityExpressed in the thymus, thyroid, lung, trachea, esophagus, stomach, small intestine, colon, testis, prostate, ovary, uterus, placenta, and mammary and salivary glands. Expressed in carcinomas arising from some of these epithelia, such as lung cancers, squamous cell carcinomas of the upper aerodigestive tract, mammary carcinomas, biliary tract, colon, and cervix cancers. Minimally or not expressed in the normal pancreas or chronic pancreatitis, but is highly expressed in pancreatic tumors and pancreatic tumor cell lines. {ECO:0000269|PubMed:10024507, ECO:0000269|PubMed:10880978, ECO:0000269|PubMed:10920259, ECO:0000269|PubMed:16814944}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs2259292  rs3107764  rs2293232  rs2246901  rs3749331  rs2259292  rs2293232  rs2246901 
Subcellular location [CC][Mucin-4 beta chain]: Cell membrane {ECO:0000303|PubMed:10880978};
Single-pass membrane protein {ECO:0000303|PubMed:10880978}. Note=Isoforms lacking the Cys-rich region, EGF-like domains and transmembrane region are secreted. Secretion occurs by splicing or proteolytic processing. {ECO:0000269|PubMed:12102554, ECO:0000303|PubMed:10880978}.;
[Mucin-4 alpha chain]: Cell membrane {ECO:0000303|PubMed:10880978}. Secreted {ECO:0000269|PubMed:12102554}. Note=Forms a complex with Mucin-4 beta chain at the cell membrane. {ECO:0000305|PubMed:10880978}.;
[Isoform 3]: Cell membrane {ECO:0000303|PubMed:10880978};
Single-pass membrane protein {ECO:0000303|PubMed:10880978}.;
[Isoform 11]: Secreted {ECO:0000303|PubMed:10880978}.;
[Isoform 15]: Secreted {ECO:0000303|PubMed:10880978}.;
[Isoform 17]: Cell membrane {ECO:0000303|PubMed:10880978};
Single-pass membrane protein {ECO:0000303|PubMed:10880978}.
Mouse PG classificationNA
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