| Gene Information | |
|---|---|
| Gene Name | SKAP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 359 |
| Protein Names | Src kinase-associated phosphoprotein 1 (Src family-associated phosphoprotein 1) (Src kinase-associated phosphoprotein of 55 kDa) (SKAP-55) (pp55) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000141293 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q86WV1 |
| Gene Card | SKAP1 |
| Uniprot ID | Q86WV1 |
| Pfam | PF00169; PF00018 |
| In ASD | no |
| Allosteric Prediction | no (-0.51191486) |
| Ortholog in Animals | Alpaca_ SKAP1 ( ortholog_one2one ) Dog_ SKAP1 ( ortholog_one2one ) GuineaPig_ SKAP1 ( ortholog_one2one ) Macaque_ SKAP1 ( ortholog_one2one ) Mouse_ Skap1 ( ortholog_one2one ) Pig_ SKAP1 ( ortholog_one2one ) Rat_ Skap1 ( ortholog_one2one ) Rabbit_ SKAP1 ( ortholog_one2one ) |
| Ohnologs | SKAP2 |
| Paralogs | SKAP2 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level). {ECO:0000269|PubMed:9195899}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1U5D (X-ray 1.70A ) |
| DBSNP | rs2278868 rs35288886 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:9671755}. Nucleus {ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:9671755}. Cell membrane {ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:9671755}. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane. {ECO:0000269|PubMed:9671755}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |