| Gene Information | |
|---|---|
| Gene Name | VGF |
| Organism | Homo sapiens (Human) |
| Gene Length | 615 |
| Protein Names | Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-62; Antimicrobial peptide VGF[554-577]] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000128564 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | O15240 |
| Gene Card | VGF |
| Uniprot ID | O15240 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | yes (0.181951117) |
| Ortholog in Animals | Dog_ VGF ( ortholog_one2one ) GuineaPig_ VGF ( ortholog_one2one ) Macaque_ VGF ( ortholog_one2one ) Mouse_ Vgf ( ortholog_one2one ) Pig_ VGF ( ortholog_one2one ) Rat_ Vgf ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | brain, cerebral.cortex, hypothalamus, pituitary.gland |
| Tissue Specificity | Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells. {ECO:0000269|PubMed:19194657}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7D13 (NMR - ) 7D16 (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | [Neurosecretory protein VGF]: Secreted {ECO:0000269|PubMed:19194657}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:19194657}. Note=Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus. |
| Mouse PG classification | NA |
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