Gene Information
Gene NameSMC6
OrganismHomo sapiens (Human)
Gene Length1091
Protein NamesStructural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6)
Target NameNA
Target TypeNA
Gene Age>4290 ( ENSG00000163029 )
Evolutionary StageEukaryota
AlphaFoldDBQ96SB8
Gene CardSMC6
Uniprot IDQ96SB8
PfamPF02463
In ASDno
Allosteric Predictionno (-0.535805809)
Ortholog in AnimalsAlpaca_ SMC6 ( ortholog_one2one )
Dog_ SMC6 ( ortholog_one2one )
GuineaPig_ SMC6 ( ortholog_one2one )
Macaque_ SMC6 ( ortholog_one2one )
Mouse_ Smc6 ( ortholog_one2one )
Pig_ SMC6 ( ortholog_one2one )
Rat_ Smc6 ( ortholog_one2one )
OhnologsNA
ParalogsSMC5
TissueNA
Tissue SpecificityWidely expressed (PubMed:11408570). Strongly expressed in testis (PubMed:11408570). {ECO:0000269|PubMed:11408570}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs35195207  rs1065381  rs35257753  rs10221907 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:11408570, ECO:0000269|PubMed:25931565, ECO:0000269|PubMed:35263599}. Nucleus speckle {ECO:0000269|PubMed:11408570}. Chromosome {ECO:0000250|UniProtKB:Q924W5}. Nucleus, PML body {ECO:0000269|PubMed:17589526}. Chromosome, telomere {ECO:0000269|PubMed:17589526}. Note=Colocalizes with SMC5 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (By similarity). Localizes to PML nuclear bodies in ALT cell lines (PubMed:17589526). Associates with chromatin (PubMed:25931565). Accumulates with RAD18 and the SLF1-SLF2 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). Localizes in interchromatin granule clusters (PubMed:11408570). {ECO:0000250|UniProtKB:Q924W5, ECO:0000269|PubMed:11408570, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:25931565}.
Mouse PG classificationNA
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