| Gene Information | |
|---|---|
| Gene Name | WNT5A |
| Organism | Homo sapiens (Human) |
| Gene Length | 380 |
| Protein Names | Protein Wnt-5a |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000114251 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P41221 |
| Gene Card | WNT5A |
| Uniprot ID | P41221 |
| Pfam | PF00110 |
| In ASD | no |
| Allosteric Prediction | yes (0.646728373) |
| Ortholog in Animals | Alpaca_ WNT5A ( ortholog_one2one ) Dog_ WNT5A ( ortholog_one2one ) GuineaPig_ WNT5A ( ortholog_one2one ) Macaque_ WNT5A ( ortholog_one2one ) Mouse_ Wnt5a ( ortholog_one2one ) Pig_ WNT5A ( ortholog_one2one ) Rat_ Wnt5a ( ortholog_one2one ) Rabbit_ WNT5A ( ortholog_one2one ) |
| Ohnologs | WNT5B, WNT7A, WNT7B, WNT2B, WNT4 |
| Paralogs | WNT6, WNT3, WNT4, WNT2B, WNT2, WNT9B, WNT16, WNT8B, WNT11, WNT3A, WNT7B, WNT5B, WNT10A, WNT9A, WNT7A, WNT10B, WNT1, WNT8A |
| Tissue | NA |
| Tissue Specificity | Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level) (PubMed:15735754). Detected in neonate heart and lung (PubMed:8288227). {ECO:0000269|PubMed:15735754, ECO:0000269|PubMed:8288227}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs786200925 rs387906663 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}. |
| Mouse PG classification | HPG |
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