| Gene Information | |
|---|---|
| Gene Name | VEGFA |
| Organism | Homo sapiens (Human) |
| Gene Length | 232 |
| Protein Names | Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF) |
| Target Name | vascular endothelial growth factor a |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000112715 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P15692 |
| Gene Card | VEGFA |
| Uniprot ID | P15692 |
| Pfam | PF00341; PF14554 |
| In ASD | no |
| Allosteric Prediction | yes (1.286538814) |
| Ortholog in Animals | Alpaca_ VEGFA ( ortholog_one2one ) Dog_ VEGFA ( ortholog_one2one ) Macaque_ VEGFA ( ortholog_one2one ) Mouse_ Vegfa ( ortholog_one2one ) Pig_ VEGFA ( ortholog_one2one ) Rat_ Vegfa ( ortholog_one2one ) Rabbit_ VEGFA ( ortholog_one2one ) |
| Ohnologs | VEGFC |
| Paralogs | VEGFD, VEGFC, PGF, VEGFB |
| Tissue | NA |
| Tissue Specificity | Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland. {ECO:0000269|PubMed:22009797}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1BJ1 (X-ray 2.40A ) 1CZ8 (X-ray 2.40A ) 1FLT (X-ray 1.70A ) 1KAT (NMR - ) 1KMX (NMR - ) 1MJV (X-ray 2.10A ) 1MKG (X-ray 2.50A ) 1MKK (X-ray 1.32A ) 1QTY (X-ray 2.70A ) 1TZH (X-ray 2.60A ) 1TZI (X-ray 2.80A ) 1VGH (NMR - ) 1VPF (X-ray 2.50A ) 1VPP (X-ray 1.90A ) 2FJG (X-ray 2.80A ) 2FJH (X-ray 3.10A ) 2QR0 (X-ray 3.50A ) 2VGH (NMR - ) 2VPF (X-ray 1.93A ) 3BDY (X-ray 2.60A ) 3P9W (X-ray 2.41A ) 3QTK (X-ray 1.85A ) 3S1B (X-ray 2.90A ) 3S1K (X-ray 2.55A ) 3V2A (X-ray 3.20A ) 4DEQ (X-ray 2.65A ) 4GLN (X-ray 1.60A ) 4GLS (X-ray 1.60A ) 4KZN (X-ray 1.71A ) 4QAF (X-ray 1.80A ) 4WPB (X-ray 3.11A ) 4ZFF (X-ray 2.75A ) 5DN2 (X-ray 1.95A ) 5FV1 (X-ray 2.70A ) 5FV2 (X-ray 3.45A ) 5HHC (X-ray 2.10A ) 5HHD (X-ray 2.10A ) 5O4E (X-ray 2.15A ) 5T89 (X-ray 4.00A ) 6BFT (X-ray 2.55A ) 6D3O (X-ray 3.10A ) 6T9D (X-ray 2.90A ) 6V7K (X-ray 2.50A ) 6Z13 (X-ray 1.80A ) 6Z3F (X-ray 2.10A ) 6ZBR (X-ray 1.60A ) 6ZCD (X-ray 1.80A ) 6ZFL (X-ray 1.60A ) 7KEZ (X-ray 2.31A ) 7KF0 (X-ray 2.32A ) 7KF1 (X-ray 2.45A ) 7LL8 (X-ray 2.31A ) 7LL9 (X-ray 2.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:11563986, ECO:0000269|PubMed:11731620, ECO:0000269|PubMed:15896327}. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a significant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin. |
| Mouse PG classification | NA |
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