| Gene Information | |
|---|---|
| Gene Name | VDR |
| Organism | Homo sapiens (Human) |
| Gene Length | 427 |
| Protein Names | Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1) |
| Target Name | vitamin d3 receptor |
| Target Type | Successful target |
| Gene Age | 810 ( ENSG00000111424 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P11473 |
| Gene Card | VDR |
| Uniprot ID | P11473 |
| Pfam | PF00104; PF00105 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000102596) |
| Ortholog in Animals | Alpaca_ VDR ( ortholog_one2one ) Dog_ VDR ( ortholog_one2one ) GuineaPig_ VDR ( ortholog_one2one ) Macaque_ VDR ( ortholog_one2one ) Mouse_ Vdr ( ortholog_one2one ) Pig_ VDR ( ortholog_one2one ) Rat_ Vdr ( ortholog_one2one ) Rabbit_ VDR ( ortholog_one2one ) |
| Ohnologs | NR1I2 |
| Paralogs | NR1H4, RARG, NR1D2, RARA, PPARD, NR1H2, RORC, THRB, NR1D1, NR1H3, NR1I2, PPARG, NR1I3, RARB, RORB, PPARA, RORA, THRA |
| Tissue | bone.marrow, colon |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.03125(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1DB1 (X-ray 1.80A ) 1IE8 (X-ray 1.52A ) 1IE9 (X-ray 1.40A ) 1KB2 (X-ray 2.70A ) 1KB4 (X-ray 2.80A ) 1KB6 (X-ray 2.70A ) 1S0Z (X-ray 2.50A ) 1S19 (X-ray 2.10A ) 1TXI (X-ray 1.90A ) 1YNW (X-ray 3.00A ) 2HAM (X-ray 1.90A ) 2HAR (X-ray 1.90A ) 2HAS (X-ray 1.96A ) 2HB7 (X-ray 1.80A ) 2HB8 (X-ray 2.00A ) 3A2I (X-ray 3.27A ) 3A2J (X-ray 2.70A ) 3A3Z (X-ray 1.72A ) 3A40 (X-ray 1.45A ) 3A78 (X-ray 1.90A ) 3AUQ (X-ray 2.64A ) 3AUR (X-ray 2.21A ) 3AX8 (X-ray 2.60A ) 3AZ1 (X-ray 1.50A ) 3AZ2 (X-ray 1.69A ) 3AZ3 (X-ray 1.36A ) 3B0T (X-ray 1.30A ) 3CS4 (X-ray 2.00A ) 3CS6 (X-ray 1.80A ) 3KPZ (X-ray 1.90A ) 3M7R (X-ray 1.80A ) 3OGT (X-ray 1.75A ) 3P8X (X-ray 1.70A ) 3TKC (X-ray 1.75A ) 3VHW (X-ray 2.43A ) 3W0A (X-ray 1.80A ) 3W0C (X-ray 1.90A ) 3W0Y (X-ray 1.98A ) 3WGP (X-ray 2.00A ) 3WWR (X-ray 3.18A ) 3X31 (X-ray 2.11A ) 3X36 (X-ray 1.93A ) 4G2I (X-ray 1.80A ) 4ITE (X-ray 2.49A ) 4ITF (X-ray 2.84A ) 5GT4 (X-ray 1.83A ) 5V39 (X-ray 2.20A ) 5YSY (X-ray 2.00A ) 5YT2 (X-ray 2.00A ) |
| DBSNP | rs121909790 rs121909797 rs121909794 rs121909791 rs121909793 rs121909795 rs11574090 rs121909796 rs121909798 rs121909799 rs267607169 rs11574115 rs121909800 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:12145331, ECO:0000269|PubMed:16207705, ECO:0000269|PubMed:28698609}. Cytoplasm {ECO:0000269|PubMed:12145331, ECO:0000269|PubMed:16207705, ECO:0000269|PubMed:28698609}. Note=Localizes mainly to the nucleus (PubMed:28698609, PubMed:12145331). Translocated into the nucleus via both ligand-dependent and ligand-independent pathways; ligand-independent nuclear translocation is mediated by IPO4 (PubMed:16207705). {ECO:0000269|PubMed:12145331, ECO:0000269|PubMed:16207705, ECO:0000269|PubMed:28698609}. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |